Standard management of sickle cell disease complications
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King Faisal Specialist Hospital and Research Centre
Abstract
Sickle cell disease remains a major public health concern in sub-Saharan Africa, Europe, and the United States. The survival rate of children and adolescents has increased immensely in developed countries, whereas the survival rate for adults lagged behind. The increase in the pediatric survival rate is attributable to the institution of hydroxyurea treatment as well as stroke prevention strategies. In this review, we discuss the management of the sickle disease major complications such as pain, stroke, and acute chest syndrome with the most current hydroxyurea use and transfusion therapy. © 2020 King Faisal Specialist Hospital & Research Centre
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Keywords
Acute chest syndrome, Hydroxyurea and transfusion, Sickle cell disease, Adolescent, Anemia, sickle cell, Blood transfusion, Child, Child, preschool, Female, Humans, Male, Chelating agent, Glutamine, Hemoglobin f, Hemoglobin s, Hydroxyurea, Cerebrovascular accident, Chronic organ complication, Complication, Disease management, Gene mutation, Human, Infection, Iron overload, Leg ulcer, Leukemia, Long term care, Malignant neoplasm, Pain, Pathophysiology, Pregnancy, Review, Risk benefit analysis, Sickle cell anemia, Side effect, Spermatogenesis, Treatment indication, Vein occlusion, Preschool child, Procedures