Myocardial proteases and cardiac remodeling
Loading...
Date
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Wiley-Liss Inc.
Abstract
Cardiac hypertrophy (CH), characterized by the enlargement of cardiomyocytes, fibrosis and apoptosis, is one of the leading causes of death worldwide. Despite the advances in cardiovascular research, there remains a need to further investigate the signaling pathways that mediate CH in order to identify novel therapeutic targets. One of the hallmarks of CH is the remodeling of the extracellular matrix (ECM). Multiple studies have shown an important role of cysteine proteases and matrix metalloproteinases (MMPs) in the remodeled heart. This review focuses on the role of cysteine cathepins and MMPs in cardiac remodeling. © 2017 Wiley Periodicals, Inc.
Description
Keywords
Cardiac remodeling, Cathepsins, Extracellular matrix, Heart failure, Matrix metalloproteinases, Animals, Humans, Hypertension, Myocardium, Peptide hydrolases, Ventricular remodeling, Cathepsin, Cathepsin b, Heart enzyme, Isoenzyme, Matrix metalloproteinase, Proteinase, Peptide hydrolase, Cardiac muscle, Cardiovascular disease, Cardiovascular system, Clinical trial (topic), Congestive cardiomyopathy, Enzyme activity, Enzyme structure, Heart protection, Heart ventricle hypertrophy, Heart ventricle remodeling, Human, Molecular pathology, Ph, Priority journal, Protein function, Protein structure, Protein synthesis, Regulatory mechanism, Review, Animal, Enzymology, Metabolism