Myocardial proteases and cardiac remodeling

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dc.contributor.authorRiaz, Sadaf
dc.contributor.authorZeidan, Asad
dc.contributor.authorMraiche, Fatima
dc.contributor.departmentAnatomy, Cell Biology, and Physiological Sciences
dc.contributor.facultyFaculty of Medicine (FM)
dc.contributor.institutionAmerican University of Beirut
dc.date.accessioned2025-01-24T11:36:41Z
dc.date.available2025-01-24T11:36:41Z
dc.date.issued2017
dc.description.abstractCardiac hypertrophy (CH), characterized by the enlargement of cardiomyocytes, fibrosis and apoptosis, is one of the leading causes of death worldwide. Despite the advances in cardiovascular research, there remains a need to further investigate the signaling pathways that mediate CH in order to identify novel therapeutic targets. One of the hallmarks of CH is the remodeling of the extracellular matrix (ECM). Multiple studies have shown an important role of cysteine proteases and matrix metalloproteinases (MMPs) in the remodeled heart. This review focuses on the role of cysteine cathepins and MMPs in cardiac remodeling. © 2017 Wiley Periodicals, Inc.
dc.identifier.doihttps://doi.org/10.1002/jcp.25884
dc.identifier.eid2-s2.0-85019856182
dc.identifier.pmid28255990
dc.identifier.urihttp://hdl.handle.net/10938/28683
dc.language.isoen
dc.publisherWiley-Liss Inc.
dc.relation.ispartofJournal of Cellular Physiology
dc.sourceScopus
dc.subjectCardiac remodeling
dc.subjectCathepsins
dc.subjectExtracellular matrix
dc.subjectHeart failure
dc.subjectMatrix metalloproteinases
dc.subjectAnimals
dc.subjectHumans
dc.subjectHypertension
dc.subjectMyocardium
dc.subjectPeptide hydrolases
dc.subjectVentricular remodeling
dc.subjectCathepsin
dc.subjectCathepsin b
dc.subjectHeart enzyme
dc.subjectIsoenzyme
dc.subjectMatrix metalloproteinase
dc.subjectProteinase
dc.subjectPeptide hydrolase
dc.subjectCardiac muscle
dc.subjectCardiovascular disease
dc.subjectCardiovascular system
dc.subjectClinical trial (topic)
dc.subjectCongestive cardiomyopathy
dc.subjectEnzyme activity
dc.subjectEnzyme structure
dc.subjectHeart protection
dc.subjectHeart ventricle hypertrophy
dc.subjectHeart ventricle remodeling
dc.subjectHuman
dc.subjectMolecular pathology
dc.subjectPh
dc.subjectPriority journal
dc.subjectProtein function
dc.subjectProtein structure
dc.subjectProtein synthesis
dc.subjectRegulatory mechanism
dc.subjectReview
dc.subjectAnimal
dc.subjectEnzymology
dc.subjectMetabolism
dc.titleMyocardial proteases and cardiac remodeling
dc.typeReview

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