Emerging genetic biomarkers in lung adenocarcinoma
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SAGE Publications Ltd
Abstract
Comprehensive genomic profiling is a next-generation sequencing approach used to detect several known and emerging genomic alterations. Many genomic variants detected by comprehensive genomic profiling have become recognized as significant cancer biomarkers, leading to the development of major clinical trials. Lung adenocarcinoma has become one of the most targeted cancers for genomic profiling with a series of actionable mutations such as EGFR, KRAS, HER2, BRAF, FGFR, MET, ALK, and many others. The importance of these mutations lies in establishing targeted therapies that significantly change the outcome in lung adenocarcinoma besides the prognostic value of some mutations. This review sheds light on the development of the comprehensive genomic profiling field, mainly lung adenocarcinoma, and discusses the role of a group of mutations in this disease. © The Author(s) 2022.
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Keywords
Actionable mutations, Comprehensive genomic profiling, Lung cancer, Next-generation sequencing, Targeted therapy, Afatinib, Alectinib, Anaplastic lymphoma kinase, B raf kinase, Biological marker, Brain derived neurotrophic factor, Brigatinib, Capmatinib, Cetuximab, Crizotinib, Dabrafenib, Dovitinib, Entrectinib, Epidermal growth factor receptor, Epidermal growth factor receptor 2, Erlotinib, Fibroblast growth factor receptor, Gamma urogastrone, Gefitinib, Glesatinib, Ipilimumab, K ras protein, Lapatinib, Larotrectinib, Lenvatinib, Lorlatinib, Merestinib, Nivolumab, Osimertinib, Panitumumab, Pertuzumab, Poziotinib, Programmed death 1 ligand 1, Programmed death 1 receptor, Protein ret, Ras protein, Scatter factor receptor, Tarloxotinib, Temsirolimus, Tepotinib, Trastuzumab, Trastuzumab emtansine, Akt/mtor signaling, Angiogenesis, Apoptosis, Autophosphorylation, Breast cancer, Cell proliferation, Chemoradiotherapy, Dna sequencing, Echinoderm, Egfr signaling, Fluorescence in situ hybridization, Gene, Gene amplification, Gene expression, Gene expression profiling, Genetic profile, Genetic transcription, High throughput sequencing, Histology, Human, In situ hybridization, Jak-stat signaling, Liver regeneration, Lung adenocarcinoma, Mapk signaling, Molecularly targeted therapy, Mutation, Non small cell lung cancer, Pi3k/akt signaling, Prevalence, Protein phosphorylation, Review, Rna sequence, Ros1 gene, Somatic mutation, Stomach cancer, Tumor microenvironment, Tumor mutational burden