Promising anti-diabetic effect of dextran sulfate sodium: Is it its clinical come back?

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dc.contributor.authorNoureldein, Mohamed H.
dc.contributor.authorDia, Batoul A.
dc.contributor.authorNabbouh, Ali I.
dc.contributor.authorEid, Assaad A.
dc.contributor.departmentAnatomy, Cell Biology, and Physiological Sciences
dc.contributor.facultyFaculty of Medicine (FM)
dc.contributor.institutionAmerican University of Beirut
dc.date.accessioned2025-01-24T11:36:59Z
dc.date.available2025-01-24T11:36:59Z
dc.date.issued2020
dc.description.abstractClinical studies showed that dextran sulfate sodium (DSS) alleviates stroke, diabetic retinopathy and hypercholesterolemia, yet its mechanism of action was unrevealed. This study show that DSS reduces hyperglycemia, plasma insulin and enhances glucose utilization by attenuating ROS production, suggesting a novel therapeutic use of DSS in diabetes and its complication. © 2019 Elsevier B.V.
dc.identifier.doihttps://doi.org/10.1016/j.diabres.2019.03.016
dc.identifier.eid2-s2.0-85063096134
dc.identifier.pmid30880091
dc.identifier.urihttp://hdl.handle.net/10938/28770
dc.language.isoen
dc.publisherElsevier Ireland Ltd
dc.relation.ispartofDiabetes Research and Clinical Practice
dc.sourceScopus
dc.subjectDiabetes
dc.subjectDiabetes complications
dc.subjectHypoglycemic agents
dc.subjectAnimals
dc.subjectDextran sulfate
dc.subjectDiabetes mellitus
dc.subjectHumans
dc.subjectMale
dc.subjectMice
dc.subjectGlucose
dc.subjectInsulin
dc.subjectReactive oxygen metabolite
dc.subjectSuperoxide
dc.subjectAntidiabetic agent
dc.subjectAnimal experiment
dc.subjectAnimal model
dc.subjectAnimal tissue
dc.subjectAntidiabetic activity
dc.subjectArticle
dc.subjectControlled study
dc.subjectDrug mechanism
dc.subjectGlucose blood level
dc.subjectGlucose utilization
dc.subjectHyperglycemia
dc.subjectInsulin blood level
dc.subjectMouse
dc.subjectNon insulin dependent diabetes mellitus
dc.subjectNonhuman
dc.subjectOral glucose tolerance test
dc.subjectPancreas tissue
dc.subjectAnimal
dc.subjectHuman
dc.titlePromising anti-diabetic effect of dextran sulfate sodium: Is it its clinical come back?
dc.typeArticle

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