Angioprevention in Colon Cancer from Bench to Bedside
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Date
2015
Journal Title
Journal ISSN
Volume Title
Publisher
Current Medicine Group LLC 1
Abstract
Colon cancer is a deadly disease with an indolent growth pattern that provides a window of opportunity for early detection and a platform for effective prevention. Angiogenesis has been implicated in the transformation of a colonic adenoma into polyp and ultimately into cancer, invading the neighboring tissue and gaining access to systemic circulation before seeding into distant organs. The “angiogenic switch” that occurs early during the preneoplastic stages could be controlled by “angiopreventive” agents before phenotypic and molecular changes result in the progression from dysplasia to invasive cancer. Here, we review the anti-angiogenic agents used in early epidemiologic studies and discuss the new dietary compounds that have a potential role in angioprevention. © 2015, Springer Science+Business Media New York.
Description
Keywords
Angiogenesis, Angioprevention, Colon cancer, Hypoxia-inducible factor α, Nitric oxide synthase, Nuclear factor kappa β, Vascular endothelial growth factor, 2 (3,4 dihydroxyphenil)ethanol, 5 methylselenocysteine, Acetylsalicylic acid, Alfacalcidol, Allium fistulosum extract, Angiogenesis inhibitor, Calcitriol, Curcumin, Deguelin, Epigallocatechin gallate, Flavone derivative, Garlic extract, Glycyrrhizic acid, Grape seed extract, Hydroxymethylglutaryl coenzyme a reductase inhibitor, Nonsteroid antiinflammatory agent, Olive oil, Plant extract, Polymethoxyflavone, Polyphenol, Proanthocyanidin, Selenocysteine, Silibinin, Unclassified drug, Aberrant crypt focus, Antiangiogenic activity, Breast cancer, Cancer mortality, Cancer prevention, Colon carcinoma, Colon polyp, Colon tumor, Colorectal adenoma, Colorectal cancer, Colorectal carcinoma, Diet supplementation, Drug dose escalation, Human, Lung cancer, Malignant transformation, Nonhuman, Raspberry, Review, Selenium blood level, Single drug dose, Skin cancer, Tea, Vitamin d deficiency, Welsh onion