Sotalol as an effective adjunct therapy in the management of supraventricular tachycardia induced fetal hydrops fetalis
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IOS Press
Abstract
Sustained fetal supraventricular tachycardia (SVT) complicated by hydrops fetalis carries a significant risk of morbidity and mortality. While there is no clear consensus on first- and second-line therapy options for the management of fetal SVT with or without hydrops fetalis, there exists significant nonrandomized experience with a number of antiarrhythmic agents that has founded the basis for management. Furthermore, recently published meta-analyses and ongoing multicenter prospective studies have aimed to bridge the gap in the literature. We report two cases of sustained fetal SVT with severe secondary hydrops fetalis managed successfully with flecainide-sotalol combination therapy in one case and sotalol-digoxin combination therapy in the second and review the literature for the management of fetal SVT. © 2020 - IOS Press and the authors. All rights reserved.
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Keywords
Hydrops fetalis, Sotalol, Supraventricular tachycardia, Adult, Anti-arrhythmia agents, Digoxin, Drug therapy, combination, Female, Fetal diseases, Flecainide, Humans, Pregnancy, Tachycardia, supraventricular, Young adult, Thiamazole, Antiarrhythmic agent, Ascites, Bradycardia, Case report, Clinical article, Drug dose increase, Drug dose reduction, Drug efficacy, Drug substitution, Drug withdrawal, Echocardiography, Electrocardiogram, Electrolyte blood level, Emergency ward, Fetus echography, Fetus heart rate, Fetus hydrops, Follow up, Gestational age, Graves disease, Heart function, Heart rate, Hospital admission, Hospital discharge, Human, Hyperthyroidism, Managed care, Mitral valve regurgitation, Patient referral, Pediatric cardiology, Pericardial effusion, Pleura effusion, Priority journal, Prospective study, Qrs interval, Qtc interval, Review, Sinus rhythm, Tachycardia, Tertiary care center, Thyroid function test, Tricuspid valve regurgitation, Combination drug therapy, Complication, Diagnostic imaging, Fetus disease