Browsing by Author "Department of Pharmacology and Toxicology"

Now showing items 1-20 of 34

Alpha-2c Adrenoceptor promotes the malignant phenotype of human colon cancer cells

Njeim, Rachel Michel (2018)

Introduction: Cancer remains one of the leading causes of death worldwide, with colorectal cancer (CRC) being the third most common type. Accumulating evidence shows that stress plays a pivotal role in the malignant phenotype ...
Anti-inflammatory Approaches to Mitigate Endothelial Dysfuntion in Early Metabolic Impairment

Alaaeddine, Rana (2/7/2022)

Endothelial dysfunction is a hallmark of diabetic vasculopathies. Although hyperglycemia is believed to be the culprit causing endothelial damage, the mechanism underlying early endothelial insult in prediabetes remains ...
Association of the Cytotoxic Effects of Waterpipe and Cigarette Smoke Extract with Epigenetic Changes in Breast Cancer Cells

Kabbani, Dania (7/14/2021)

Background Smoking is one of the preventable leading causes of diseases and premature death worldwide. In Lebanon, smoking is a main public concern as it scored one of the highest smoking rate in the Eastern Mediterranean ...
Association of the Cytotoxic Effects of Waterpipe and Cigarette Smoke Extract with Relative Telomere Length (RTL) in Breast Cancer Cell Lines

Abdel Karim, Carole (4/20/2021)

Background: Breast cancer ranks the first leading cause of cancer worldwide in 2020 as declared by the International Agency for Research on Cancer (IARC). Breast cancer development and progression involve a wide range of ...
Cadmium induces migration of colon cancer cells : the roles of reactive oxygen species, p38 and Cyclooxygenase-2

Naji, Sara Chafik (2018)

Background: Increasing evidence shows that exposure to environmental pollutants such as heavy metals is positively correlated with colorectal malignancy. Cadmium (Cd) is a heavy metal contaminant whose toxicity has been ...
The Cardiorenal Effects of IL-33 Treatment in Myocardial Infarction-Induced Kidney Damage

Amin, Ghadir Ali (2/28/2021)

Myocardial infarction (MI) is a major public health concern and a leading cause of acute kidney injury through the cardio-renal interrelationship, otherwise known as type I cardio-renal syndrome. Interleukin (IL)-33, a ...
Comparative study on blockade of the norepinephrine transporter, uptake-1 by drugs of different chemical classes and the role of nitric oxide in the blockade -

El-Khoury, Catherina Nicolas (2014)

Evidence on the role of nitric oxide in modulating the activity of the norepinephrine transporter known as uptake-1 is scarce. The few studies available in the literature provide conflicting evidence on the subject. In ...
Dietary Phosphate Reduces Hypertension, Inflammation and End Organ Damage

El Atie, Yara (9/8/2021)

Hypertension remains an increasing global health burden. Previous research has shown that dietary phosphate can modulate cardiovascular disease (CVD), yet the precise mechanism of how dietary phosphate contributes to blood ...
THE DIFFERENTIAL IMPACT OF HEART FAILURE MEDICATIONS ON BASAL INFLAMMATION IN HEART FAILURE PATIENTS

KATAYA, RAYAN (2024-02-05)

Inflammation is a frequent occurrence in individuals suffering from chronic heart failure (CHF) and baseline inflammation can start as early as stage A heart failure. In response to heart failure, compensatory neurohormones ...
DNA Methylation Changes Associated with Acute and Chronic Exposure of Waterpipe and Cigarette Smoke in A549 Cell Line

Chanan, Ghenwa (2023-09-04)

Introduction: The tobacco epidemic is one of the biggest public health threats worldwide. Epidemiological studies showed that tobacco smoking increases the risk of developing several types of cancer, including lung cancer. ...
EARLY METABOLIC DYSFUNCTION AGGRAVATES THE MOTOR AND COGNITIVE CONSEQUENCES OF CAROTID ARTERY LIGATION: IMPACT OF ANTITHROMBOTIC DRUG TREATMENT

Ghazi, Alaa (9/3/2021)

Stroke is a predominant cause of death and disability globally. Extensive evidence support a link between poorly controlled blood glucose, diabetes mellitus, elevated stroke risk, and worsened functional outcomes after ...
The Effect of Cigarette Smoking on the Heart in Male Mice and in Ovariectomized and Non-Ovariectomized Female Mice

Al Shall, Maryam (2/10/2023)

Cigarette smoking (CS) is a predominant risk factor for cardiovascular disease progression worldwide. There is ample evidence of gender-based disparities in CVDs, with premenopausal females being less susceptible to the ...
The Effect of Chronic Cigarette Smoking on the Kidneys in Male Mice and In Ovariectomized and Non-Ovariectomized Female Mice

El Mokdad, Tania (2/10/2023)

Chronic Cigarette Smoking (CS), a well-known risk factor for numerous diseases, has been shown to play a significant influence in renal disorders in both females and males. The progression of chronic kidney disease (CKD) ...
Effect of hyper-caloric intake on hemodynamic functions and cardiac autonomic control : potential modulation by anti-diabetic drugs

Al Assi, Ola Ahmad (2017)

Diabetes mellitus remains a public health challenge with considerable disease and economic consequences. Mortality and morbidity due to diabetes are related to the poor cardiovascular outcomes. A significant body of research ...
THE EPIGENETIC CHANGES ASSOCIATED WITH ACUTE AND CHRONIC EXPOSURE TO CIGARETTE AND WATERPIPE SMOKE EXTRACTS ON A COLON CANCER CELL LINE

El Batch, Jana (2023-09-04)

Introduction Tobacco smoking is a major public health issue worldwide, and it has been linked to various health risks, including colon cancer. While the link between cigarette smoking and colon cancer is well established, ...
Evaluation of Aromatic Hydrocarbon Receptor Repressor (AHRR) as a Sensitive Biomarker of Ambient Polyaromatic Hydrocarbons (PAH) Exposure and a Risk Factor for Coronary Artery Disease (CAD).

Ridany, Ibrahim (5/2/2022)

Background: Coronary artery disease (CAD) and morbidities from cigarette smoking and pollution are among the leading causes of deaths world-wide. CAD risk factors include pollution exposure and cigarette smoking. Cigarette ...
GDF-15 IN DIABETIC KIDNEY DISEASE: EFFECT ON CYP450 INDUCED ROS PRODUCTION

Slika, Amani (2023-08-24)

Background: Diabetic Kidney Disease (DKD) is one of the major diabetic complications and the leading cause of end-stage renal disease. The pathogenesis of DKD is complex and includes a myriad of deregulated pathways that ...
The Impact of Dietary Interventions on Cardiovascular Dysfunction and Adipose Tissue Inflammation in Non-Obese Prediabetic Rats

Dwaib, Haneen

Cardiovascular diseases are the most common and serious complications of type 2 diabetes mellites (T2DM). Recent evidence suggested that CVDs start at the earliest point of metabolic derangement in the prognosis of diabetes, ...
THE IMPACT OF ESTROGEN DEFICIENCY ON CEREBRAL HOMEOSTASIS FOLLOWING ACUTE MYOCARDIAL INFARCTION IN FEMALE MICE

El- Samadi, Lana (2024-01-24)

Acute myocardial infarction (AMI) is marked by a decline in cardiac output (CO) and a subsequent reduction in cerebral blood flow (CBF). This hypoperfusion poses a risk of brain damage and may contribute to accelerated ...
Molecular Mechanisms by which Phosphate Modulates Angiotensin II-Induced Hypertension

Jarrah, Hala (9/12/2022)

Hypertension or high blood pressure is a critical health burden. Adherence to certain diets lowers the risk of hypertension. Preliminary data have shown a significant decrease in BP in mice receiving high dietary phosphate. ...

Now showing items 1-20 of 34

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Browsing by Author "Department of Pharmacology and Toxicology"

Browsing by Author "Department of Pharmacology and Toxicology"

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