Browsing by Author "Dbaibo, Ghassan"

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CHARACTERIZATION OF THE DE NOVO CERAMIDE METABOLIC PATHWAY IN THE BCL-2 AND BCL-XL-DEPENDENT RESPONSE TO TNF-α-INDUCED APOPTOSIS IN MCF-7 CELLS

Farchoukh, Wael (8/22/2022)

Several challenges remain in the treatment of breast cancer, the world’s most prevalent cancer in women. One of these challenges, resistance to chemotherapeutic drugs, has been associated with the upregulation in the ...
DEVELOPMENT OF A LONG-LASTING HUMORAL IMMUNE RESPONSE AGAINST THE Pfizer/BioNTech mRNA-BASED VACCINE IN HEALTHY ADULT PARTICIPANTS

El Masri, Sara (5/16/2022)

In December 2019, a cluster of pneumonia cases of unknown etiology was reported in Wuhan City, China. Later, the causative agent was identified as a new member of coronaviruses, and was named SARS-CoV-2. This virus quickly ...
ENHANCING DE NOVO SYNTHESIS OF CERAMIDE CAN OVERCOME THE CrmA INHIBITION OF TNF-⍺- INDUCED APOPTOSIS

Taha, Maya (8/30/2022)

Cowpox virus encodes for the anti-apoptotic protein cytokine response modifier A (CrmA), an inhibitor of Interleukin 1-ß (IL-1) converting enzyme (ICE) also known as Caspase-1, which, in addition to inhibiting the generation ...
Factors and outcomes associated with influenza virus loads in hospitalized patients

Sabra, Reem (7/26/2021)

Annual influenza outbreaks constitute a substantial economic and public health burden accounting for 3-5 million hospitalizations and up to 645 000 deaths worldwide. Two influenza A subtypes (H1N1pdm09 and H3N2) and two ...
In Vitro Evaluation of the Cytotoxicity of Streptomyces MCH11 Extract Isolated from Lebanese Soil on A549 Lung Cancer Cells

Saif, Dalia (5/18/2022)

Bacterial extracts possess many therapeutic attributes such as antibacterial, antifungal, antiviral, antioxidant, and anticancer activities. Streptomyces is the largest genus of Actinobacteria that provides various compounds ...
Restoration of ceramide de novo synthesis by the synthetic retinoid ST1926 as it induces adult T-cell leukemia cell death

Ghandour, Botheina (20-11)

Ceramide is a potently bioactive cellular lipid with compartmentalized and tightly regulated levels. Distinct metabolic pathways lead to the generation of several ceramide species with distinguishable roles in oncogenesis, ...
Singolipidomics of Adenovirus-Infected Human Lung Adenocarcinoma Cells

Hijazi, Hasan Mohamed (9/21/2020)

Introduction: Human Adenoviruses (HAdVs) are obligate intracellular organisms that typically subvert epithelial cells by converting them into virion-producing factories. HAdVs encode a protein within the E3 region, termed ...
Sphingolipidomics of influenza A virus-infected Lung epithelial cells

Hijazi, Mariam (9/23/2020)

Introduction: Influenza virus continues to threaten humans and remains a global health concern. Influenza viruses hijack host cell machineries and impact host cell metabolism to tailor cellular pathways and resources to ...
UNDERSTANDING THE ROLE OF CERAMIDE IN p53-MEDIATED AND p53-INDEPENDENT RESPONSES TO HYPOXIA IN HCT-116 COLON CANCER CELLS

Mechleb, Karen Maroun (9/23/2020)

Hypoxia is a common feature of solid tumors resulting from the disordered vasculature developed to supply oxygen to the rapidly growing tumor. As a result, gradients of oxygen concentration emerge; regions of severe hypoxia ...

Now showing items 1-9 of 9

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Browsing by Author "Dbaibo, Ghassan"

Browsing by Author "Dbaibo, Ghassan"

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Copyright Statement