Browsing by Author "Jaffa, Ayad"

Now showing items 1-18 of 18

The Association between Diabetes and Social Determinants of Health, and Cancer in the United States: Results from the Behavioral Risk Factor Surveillance System (BRFSS)

Massouh, Nour (5/16/2022)

Several studies have found an association between diabetes and cancer, wherein the incidence of cancer was higher among diabetic patients. However, these studies did not account for the effect of social determinants of ...
CHARACTERIZATION OF THE DE NOVO CERAMIDE METABOLIC PATHWAY IN THE BCL-2 AND BCL-XL-DEPENDENT RESPONSE TO TNF-α-INDUCED APOPTOSIS IN MCF-7 CELLS

Farchoukh, Wael (8/22/2022)

Several challenges remain in the treatment of breast cancer, the world’s most prevalent cancer in women. One of these challenges, resistance to chemotherapeutic drugs, has been associated with the upregulation in the ...
Crosstalk between Bradykinin and Sphingosine-1-Phosphate Exacerbate Inflammation and Oxidative Stress in Microglia

Hassan, Nadine (9/6/2022)

Background: Neurodegenerative diseases (NDs) are a set of disorders that involve the death of neurons in the brain. These disorders are described as progressive and irreversible due to the brain’s limited regenerative ...
Effect of Succinate Dehydrogenase Inhibitors on Mouse Bone Marrow-Derived Macrophages Proliferation, Bioenergetics, and Immune Profile

Jelwan, Joseph (9/2/2022)

Background: Modern agriculture and food preservation standards require the use of fungicides to treat and prevent fungal contamination. Succinate dehydrogenase inhibitors (SDHIs) are one of the mostly used groups of ...
ENHANCING DE NOVO SYNTHESIS OF CERAMIDE CAN OVERCOME THE CrmA INHIBITION OF TNF-⍺- INDUCED APOPTOSIS

Taha, Maya (8/30/2022)

Cowpox virus encodes for the anti-apoptotic protein cytokine response modifier A (CrmA), an inhibitor of Interleukin 1-ß (IL-1) converting enzyme (ICE) also known as Caspase-1, which, in addition to inhibiting the generation ...
HEPARIN-MIMETIC ALGINATE SULFATE/POLYCAPROLACTONE DOUBLE EMULSION NANOPARTICLES FOR ENHANCED INSULIN-LIKE GROWTH FACTOR (IGF-1) DELIVERY AND DIABETIC WOUND HEALING APPLICATIONS

Fahs, Duaa (2/7/2021)

Introduction: Diabetic foot ulcers (DFUs) are a complication to diabetes mellitus that cause 85% of all amputations worldwide and pose an annual economic burden of $15 billion. The wound healing process is altered in DFU ...
Identification and Validation of Notch2 as an Interacting Partner with the Cardiomyopathy Associated Protein RBM20

Tantawi, Houda (9/23/2020)

Background: Mutations in the gene encoding the RNA-binding protein (RBM20) have recently been identified to segregate with aggressive forms of familial dilated cardiomyopathy (DCM). RBM20 has been shown to regulate splicing ...
Impact of Kallikrein Kinin System Components on Macrophages' Inflammatory Response under Normal and Hyperglycemic Conditions

Saber, Lama Mohamad (9/23/2020)

Background: Inflammation is greatly associated with the development of chronic diseases such as diabetes. Diabetes is the leading cause of death in the world since it can lead to many macrovascular and microvascular ...
Impact of Succinate Dehydrogenase Inhibitors on THP-1 Derived Human Macrophages Viability, Mitochondrial Bioenergetics, and Immune Profile

Farhoud, Mohammad (12/20/2022)

Background: Succinate dehydrogenase inhibitors (SDHIs) are active compounds in a group of fungicides used extensively worldwide particularly to limit the proliferation of molds on plants and plants products. SDHIs mediate ...
Involvement Of The Kallikrein-Kinin System In Neuro-Inflammation

Hamati, Moussa (9/1/2022)

Introduction: Traumatic brain injury (TBI) is a major cause of disability and mortality worldwide. It can occur as a primary acute injury resulting from an exterior mechanical force or a secondary injury, which can become ...
Mechanisms in the Acceleration of the Regression of Liver Injury in Chronic Liver Fibrosis in Mice

Imad, Noor (5/18/2022)

Background: Sustained chronic liver injury originating from several factors including viral infection, alcohol consumption, and hepatitis may lead to hepatic fibrosis characterized by an imbalance between extracellular ...
The Neuroprotective Effects of Edaravone in an Experimental Mouse Model of Traumatic Brain Injury

Mekhjian, Sarin (2/10/2023)

Traumatic brain injury (TBI) is a form of acquired brain injury that poses a significant threat to public health. Mild to severe TBI is rapidly being classified as a chronic disease, given that evidence indicates that ...
NOVEL ALGINATE AND ALGINATE SULFATE/POLYCAPROLACTONE NANOPARTICLES FOR ENHANCED GROWTH FACTORS DELIVERY IN WOUND HEALING APPLICATIONS

Karam, Mia (2024-01-31)

Diabetes is a metabolic disorder characterized by hyperglycemia, affecting more than 460 million people worldwide. Uncontrolled diabetes can lead to secondary complications such as diabetic foot ulcers (DFUs) due to ...
NOVEL APPROACH FOR EX-VIVO EXPANSION OF HEMATOPOIETIC STEM CELLS USING DECELLULARIZED HUMAN UMBILICAL CORD EXTRACTS

Tamzarian, Wilson Kevork (2023-09-07)

Hematopoietic stem cell transplantations (HSCT) represent so far, the only efficient reconstructive tool for damaged bone marrow (BM) in hematological disorders. The success of these regenerative strategies relies on the ...
Plasma Kallikrein as a Novel Modulator of Macrophage Dynamics

Beydoun, Maryam Mohsen (9/23/2020)

Cardiovascular diseases (CVD) remain the leading cause of death globally, by which more than 17 million individuals die each year, accounting for 30% of all deaths. Moreover, CVD is responsible for 34% of all deaths in the ...
The plasma kallikrein-kinin system as a modulator in liver injury/remodeling

Ahmed, Ibrahim (2/8/2021)

Background: Liver injury is an apparent condition of the body system owing to the numerous functions of the liver. Most of the etiologies are due to the actions of many drugs, toxins, hepatotropic viruses, and idiosyncratic ...
Racial Disparities in Cancer and its Health Determinants using US Health Information National Trends Survey “HINTS 5 CYCLE 4”

Jaouni, Mahmoud

Background: The global burden of cancer is expected to become the main cause of premature death worldwide. This risk of cancer is affected by clinical parameters and non-clinical factors referred to determinants of health. ...
ROLE OF NEWLY SYNTHESIZED CYCLOOXYGENASES IN ASPIRIN RESPONSIVENESS IN THE HUMAN MEGAKARYOBLASTIC CELL LINE MEG01

Fakih, Adham (2022-01-05)

Background: Aspirin is one of the most commonly used drugs in cardiovascular medicine. It interferes with platelet aggregation by inhibiting cyclooxygenases in blood platelets and megakaryocytes. Low-dose aspirin has at ...

Now showing items 1-18 of 18

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Browsing by Author "Jaffa, Ayad"

Browsing by Author "Jaffa, Ayad"

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