Browsing by Author "Matar, Ghassan"

Now showing items 1-19 of 19

Assessment and Characterization of an Anti-EBV Compound Extracted from Soil-Dwelling Bacteria

Saadeh, Marwan (9/6/2022)

Introduction: The Epstein Barr Virus (EBV) is thought to infect >90% of the population world-wide; the virus then establishes latency in resting memory B-cells. The virus is associated with infectious mononucleosis (IM), ...
CARBAPENEMASES, THEIR INHIBITORS, AND PERSISTER CELLS IN MDR AND XDR GRAM-NEGATIVE BACTERIA AT AUBMC

Banna, Hanin (7/26/2021)

Background: Antimicrobial resistance is posing an increasing risk to public health due to the overuse, abuse and miss-use of the available agents, especially with multi-drug resistant (MDR) and extensive-drug resistant ...
Characterization of UTI causing E.coli and K.pneumoniae clinical isolates and assessing their effect on urinary tract cells

Abdel Khalek, Pascal (9/8/2021)

Title: Characterization of UTI Causing E.coli and K.pneumoniae Clinical Isolates and Assessing their Effect on Urinary Tract Cells Background: Urinary tract infections are among the most common bacterial infections in ...
Deciphering Nature's Secret: Genome Mining in Natural Product Drug Discovery.

Hanna, Aya (2024-05-02)

Background: Antimicrobial resistance (AMR) stands as a threat against global health, rendering once-effective antibiotics impotent against bacterial infections. Various factors contribute to the emergence of AMR, including ...
Discovery of Novel Anti-Biofilm Agents from Soil Dwelling Bacteria

Khazaal, Jana (2024-05-02)

Background: ESKAPE pathogens, as classified by the World Health Organization, pose a significant threat to global healthcare due to their resistance to antimicrobial agents. Among these pathogens, Pseudomonas aeruginosa ...
Discovery of Novel Antibacterial Agents Targeting MRSA Pathogens from Unexploited Actinomycetes

Yammine, Christelle Kamal (9/23/2020)

Background: Antimicrobial resistance (AMR) has been present ever since the discovery of the first classes of antibiotics, where Sir Alexander Fleming warned about it in his Nobel Prize speech back in 1945. With the lack ...
The Effect of EBV on Inflammatory Processes in a Type 1 Autoimmune Diabetes Mellitus Mouse Model

Obeid, Hiba (2022-05-18)

Introduction: Type 1 diabetes (T1D) is considered a complex heterogeneous autoimmune disease. It occurs due to the destruction of insulin-producing beta cells of the islets of Langerhans of the pancreas. Risk factors of ...
Effect of EBV on Inflammatory Processes in a Type 1 Diabetes Mellitus Mouse Model

Kassem, Aya (5/5/2023)

The Epstein-Barr virus (EBV), also referred to as Human herpes virus 4 (HHV-4), is a double-stranded virus that belongs to the Herpesviridae family of viruses. It is estimated that this ubiquitous virus has infected more ...
Effect of Epstein-Barr Virus DNA on the Severity of Intestinal Inflammation in a Mouse Model of Acute Colitis

Andari, Sirine Imad (9/23/2020)

Background: Epstein-Barr virus (EBV) infection has been lately associated with inflammatory bowel disease (IBD), which is a collective term for chronic relapsing inflammatory disorders of the gastrointestinal tract with a ...
Establishment of a Bacteriophages Platform: Alternative Therapeutic Option

Abdo Ahmad, Tasnime (9/1/2022)

Background: Pathogenic Escherichia coli, common water contaminant, cause a large number of morbidity and mortality worldwide. Unfortunately, unrestricted use of antibiotics led to the appearance and spread of antibiotic ...
From bugs to drugs: novel anti-microbial agents from Lebanese soil and marine dwelling microorganisms

Awada, Bassel (5/9/2023)

Antimicrobial resistance (AMR) is the phenomenon by which microorganisms become non-susceptible to their originally designed drugs. AMR became a serious public health issue, as multidrug-resistant microorganisms are ...
The Interplay Between Epstein-Barr Virus DNA and the Gut Microbiota in the Pathogenesis of Rheumatoid Arthritis in a Mouse Model

Fadlallah, Sukayna (1/20/2022)

Background: The pathogenesis of rheumatoid arthritis (RA) is not fully understood; however, risk factors including genetic predisposition and environmental challenges such as infectious agents and alterations in the gut ...
Investigation of Colistin Resistance and Heteroresistance in Enterobacterales Isolates from Poultry, Water and Clinical Specimens – Role of mcr-1 genes

El Azzi, Maria Joseph (8/10/2021)

Background: The mobilized colistin resistance, mcr genes, have attracted global attention, as they confer resistance to polymyxins, one of the last-resort antimicrobials’ family for the treatment of critical infections ...
The Involvement of Viruses and Fungi in the Pathogenesis of Dental Infections

Khalil, wael (11/2/2022)

Background: Tooth related oral pathologies have been described as the most common causes of tooth loss in adults. These pathologies were mostly periodontitis, pericoronitis, and periapical infection. The involvement of ...
MOLECULAR INVESTIGATION OF EXTREMELY DRUG RESISTANT ACINETOBACTER BAUMANNII OUTBREAK IN THE ICU OF A TERTIARY HEALTHCARE CENTER IN LEBANON

Darwiche, Fatima (5/10/2023)

Antimicrobial resistance (AMR) represents one of the major global health issues today. Infections with extensively drug-resistant (XDR) and pan drug-resistant (PDR) bacteria are associated with prolonged treatment periods ...
Novel Anti-Biofilm Agents from Unexploited Soil and Marine Microorganisms

Moussa, Pamela (8/25/2021)

Background: Biofilm formation, especially on indwelling medical devices, is highly problematic and represents a crucial problem in patient care. Biofilms are considered a protective environment for the bacterial communities, ...
Severe Combined Immunodeficiency Due to a Novel Missense Mutation in IL-7R that Abolishes Surface Protein Expression

El Bsat, Yasmin Hassan (9/15/2021)

Background: Primary immunodeficiency diseases (PIDs) are a group of congenitally inherited heterogeneous disorders that result in depletion or deficiency of one or more components of the immune system. Severe Combined ...
Targeting Pre-Formed Biofilms of the Notorious Pseudomonas aeruginosa using Anidulafungin and Antibacterial Agents in in-vitro and ex-vivo Urinary Tract Infection Models

Ghanem, Nisreen Amine (9/23/2020)

Background: A crucial problem in patient care is the ability of certain bacteria, including Pseudomonas aeruginosa, to form biofilms on implanted and indwelling medical devices. P. aeruginosa biofilms play a role in ...
Utilizing NGS in AMR Surveillance in North Lebanon - A One Health Approach

Hodroj, Zeinab (5/9/2023)

Background: The global rates of antimicrobial resistance (AMR) are rising at an alarming rate with dreadful circumstances of more than 10 million deaths per year by 2050. In the Eastern Mediterranean Region (EMR), reported ...

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Browsing by Author "Matar, Ghassan"

Browsing by Author "Matar, Ghassan"

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Copyright Statement