AUB ScholarWorks

Browsing by Subject "B lymphocyte"

Browsing by Subject "B lymphocyte"

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  • Mansour, Rana; El-Orfali, Youmna; Saidu, Adam; Al-Kalamouni, Habib; Mardirossian, Hagop; Hanna-Wakim, Rima H.; Abboud, Miguel Raul; Massaad, Michel J. (Academic Press Inc., 2023)
    Background: RASGRP1-deficiency results in an immune dysregulation and immunodeficiency that manifest as autoimmunity, lymphoproliferation, lymphopenia, defective T cell function, and increased incidence of Epstein-Bar Virus ...
  • Hashash, Jana G.; Squire, Jacqueline D.; Francis, Fadi F.; Binion, David G.; Cross, Raymond Keith; Farraye, Francis A. (Wolters Kluwer Health, 2022)
    Common variable immunodeficiency (CVID) is the most common symptomatic primary immunodeficiency. It is characterized by impaired B-cell differentiation. Although patients can be diagnosed with CVID anytime during their ...
  • Merashli, Mira; Noureldine, Mohammad Hassan A.; Uthman, Imad W.; Khamashta, Munther A. (2015)
    Background: Antiphospholipid syndrome (APS) or 'Hughes syndrome' is a prothrombotic disease characterized by thrombosis and pregnancy morbidity in the presence of antiphospholipid antibodies (aPL). More than three decades ...
  • Raad, Mohamad A.; Nohra, Eden A.; Chams, Nour H.; Itani, Muhieddine M.; Talih, Farid Ramzi; Mondello, Stefania; Kobeissy, Firas H. (Elsevier Ltd, 2014)
    Despite the debilitating consequences and the widespread prevalence of brain trauma insults including spinal cord injury (SCI) and traumatic brain injury (TBI), there are currently few effective therapies for most of brain ...
  • Kazma, Jamil M.; Johnson, Cynae A.L.; Jain, Nitin B.; Gali, Vasantha Lakshmi; Young, Kenhe He; Jazaeri, Amir Anthony (Elsevier B.V., 2019)
    The involvement of the cervix as a site of relapse for hematologic malignancies is rare. We herein present a case of relapsed B-cell Acute Lymphoblastic Leukemia/Lymphoma (ALL) mimicking advanced cervical cancer. The patient ...
  • Peter, Elise; Do, Le Duy; Hannoun, S.; Muñiz-Castrillo, Sergio; Vogrig, Alberto; Wucher, Valentin; Pinto, Anne Laurie; Chounlamountri, Naura; Zakaria, Walaa; Rogemond, Véronique Dsign©ronique; Picard, Géraldine Dsign©raldine; Hédou, Julien Jacques; Ambati, Aditya S.; Alentorn, A.; Traverse-Gléhen, Alexandra; Manto, Mario Ubaldo; Psimaras, Dimitri; Mignot, Emmanuel Jean Marie; Cotton, François; Désestret, Virginie; Honnorat, Jérǒme; Bastien, Joubert (Lippincott Williams and Wilkins, 2022)
    Background and Objective s There is no report on the long-term outcomes of ataxia with antibodies against Delta and Notch-like epidermal growth factor-related (DNER). We aimed to describe the clinical-immunologic features ...
  • Dale, Bethany L.; Pandey, Arvind K.; Chen, Yuhan; Smart, Charles Duncan; Laroumanie, Fanny; Ao, Mingfang; Xiao, Liang; Dikalova, Anna E.; Dikalov, Sergey I.; Elijovich, Fernando; Foss, Jason D.; Barbaro, Natália Ruggeri; van Beusecum, Justin P.; Deǧer, Serpil Müge; Alsouqi, Aseel; Itani, Hana A.; Norlander, Allison E.; Alexander, Matthew R.; Zhao, Shilin; Ikizler, Talat Alp; Scott Algood, Holly M.; Madhur, Meena S. (American Society for Clinical Investigation, 2019)
    T and B cells have been implicated in hypertension, but the mechanisms by which they produce a coordinated response is unknown. T follicular helper (Tfh) cells that produce IL-21 promote germinal center (GC) B cell responses, ...
  • Bardawil, Tara; Khalil, Samar; Kurban, Mazen S.; Abbas, Ossama M. (Scientific Scholar, 2021)
    Differentiating cutaneous diseases that mimic each other clinically and histopathologically can at times be a challenging task for the dermatopathologist. At the same time, differentiation of entities with overlapping ...
  • El-Khoury, Riyad; Traboulsi, Sahar; Hamad, Tarek; Lamaa, Maher; Sawaya, Raja A.; Barmada, Mamdouha Abdab (Oxford University Press, 2019)
    Limb girdle muscular dystrophy type 2A (LGMD2A) is an autosomal recessive disorder characterized by progressive muscle weakness and wasting. LGMD2A is caused by mutations in the calpain-3 gene (CAPN3) that encodes a ...
  • Hamie, Lamiaa; Hamie, Maria; Kurban, Mazen S.; Abbas, Ossama M. (John Wiley and Sons Inc, 2022)
    Eosinophilic ulcer of the oral mucosa is a benign, reactive, self-limited lesion. Its pathogenesis is unclear, and it clinically manifests as a punched-out ulcer with surrounding indurated border, raising suspicion for a ...
  • Pai, Sung-yun; de Boer, Helen; Massaad, Michel J.; Chatila, T. A.; Keles, Sevgi; Jabara, Haifa H.; Janssen, Erin M.; Lehmann, Leslie E.; Hanna-Wakim, Rima H.; Dbaibo, Ghassan S.; McDonald, Douglas R.; Al-Herz, Waleed; Geha, Raif S. (Mosby Inc., 2014)
  • Al-Herz, Waleed; Chu, Julia I.; van der Spek, Jet; Raghupathy, Raj Gopal; Massaad, Michel J.; Keles, Sevgi; Biggs, Catherine M.; Cockerton, Lucinda; Chou, Janet S.; Dbaibo, Ghassan S.; Elisofon, Scott A.; Hanna-Wakim, Rima H.; Kim, Heung Bae; Lehmann, Leslie E.; McDonald, Douglas R.; Notarangelo, Luigi Daniele; Veys, Paul A.; Chatila, T. A.; Geha, Raif S.; Gaspar, Hubert Bobby; Pai, Sung-yun (Mosby Inc., 2016)
    Background Dedicator of cytokinesis 8 (DOCK8) deficiency can be cured by allogeneic hematopoietic stem cell transplantation (HSCT). Reports of outcomes are still limited. Objective We sought to analyze the results of HSCT ...
  • Chou, Janet S.; Alazami, Anas M.; Jaber, Faris; Hoyos-Bachiloglu, Rodrigo; Jones, Jennifer; Weeks, Sabrina; Alosaimi, Mohammed F.; Bainter, Wayne; Cangemi, Brittney; Badran, Yousef R.; Mohammed, Reem Walid; Alroqi, Fayhan J.; Almutairi, Abduarahman; Al-Onazi, Noufa; AlAjaji, Sulaiman; Al-Saud, Bandar K.; Arnaout, Rand Khaled H.; Elkins, Megan; Devana, Sridevi; Imperial, Juliet; Li, Betty; Drexhage, Linnea Z.; Abdel Rahman, Anas M.; Jacob, Minnie; Haddad, Hadi; Hanna-Wakim, Rima H.; Dbaibo, Ghassan S.; Massaad, Michel J.; Dasouki, Majed Jamil; Mikhael, Raymond; Baz, Zeina; Geha, Raif S.; Al-Mousa, Hamoud A. (Mosby Inc., 2020)
    Background: The gene AK2 encodes the phosphotransferase adenylate kinase 2 (AK2). Human variants in AK2 cause reticular dysgenesis, a severe combined immunodeficiency with agranulocytosis, lymphopenia, and sensorineural ...
  • Khan, Imran; Yasir, Muhammad; Azhar, Esam Ibraheem; Kumosani, Taha Abdullah; Barbour, Elie K.; Bibi, Fehmida; Kamal, Mohammad Amjad (Bentham Science Publishers B.V., 2014)
    Gut-microbiota (GM) is considered a hidden metabolic organ of the human body, providing biochemical pathways which are absent in the host. Balanced diet with calorie restriction (CR) promotes growth of healthy microbiota, ...
  • Kim, Joon-young; Nasr, Alexis; Tfayli, Hala M.; Bacha, Fida; Michaliszyn, Sara Fleet; Arslanian, Silva A. (American Diabetes Association Inc., 2017)
    Despite evidence of insulin resistance and β-cell dysfunction in glucose metabolism in youth with prediabetes, the relationship between adipose tissue insulin sensitivity (ATIS) and β-cell function remains unknown. We ...
  • Hashash, Jana G.; Hartman, Douglas J. (Academic Press Inc., 2019)
    The inflammatory mechanisms that lead to the clinical symptoms that are grouped under the term inflammatory bowel disease have not been fully characterized. Although a specific mechanism has not been identified, inflammatory ...
  • Karam, Sabine; Haidous, Mohammad; Abou Dalle, Iman; Dendooven, Amélie D.Sign©lie; Moukalled, Nour M.; van Craenenbroeck, Amaryllis H.; Bazarbachi, Ali Abdul Hamid; Sprangers, Ben (Elsevier Ireland Ltd, 2023)
    Monoclonal gammopathy of renal significance (MGRS) is a hemato-nephrological term referring to a heterogeneous group of kidney disorders characterized by direct or indirect kidney injury caused by a monoclonal immunoglobulin ...
  • Yamout, Bassem I.; Alroughani, Raed A. (Thieme Medical Publishers, Inc., 2018)
    Multiple sclerosis (MS) is a chronic central nervous system inflammatory disease of autoimmune etiology, mediated by activated T cells with evolving evidence of a significant contribution from B cells and cells of the ...
  • Harvey, Robert Donald; Carthon, Bradley C.; Lewis, Colleen M.; Hossain, Mohammad Sohrab; Zhang, Chao; Chen, Zhengjia; Harris, Wayne B.; Alese, Olatunji Boladale; Shaib, Walid L.; Bilen, Mehmet Asim; Lawson, David H.; Wu, Christina Sing Ying; Steuer, Conor Ernst; El-Rayes, Bassel F.; Khuri, Fadlo R.; Lonial, Sagar; Waller, Edmund K.; Ramalingam, Suresh S.; Owonikoko, Taofeek Kunle (Springer Nature, 2020)
    Background: Purpose: The combination of a mammalian target of rapamycin inhibitor and lenalidomide showed enhanced preclinical cytotoxicity. We conducted a phase 1 study in advanced solid tumour patients to assess safety, ...
  • Mallat, Samir G.; Itani, Houssam S.; Abou-Mrad, Rana M.; Abou-Arkoub, Rima; Tanios, Bassem Y. (Dove Medical Press Ltd., 2016)
    Rituximab is a chimeric anti-CD20 antibody that results in depletion of B-cell lymphocytes.It is currently used in the treatment of a variety of autoimmune diseases, in addition to CD20-positive lymphomas.The use of rituximab ...

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