AUB ScholarWorks

Browsing by Subject "B-Lymphocytes"

Browsing by Subject "B-Lymphocytes"

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  • DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation 
    Jabara H.H.; McDonald D.R.; Janssen E.; Massaad M.J.; Ramesh N.; Borzutzky A.; Rauter I.; Benson H.; Schneider L.; Baxi S.; Recher M.; Notarangelo L.D.; Wakim R.; Dbaibo G.; Dasouki M.; Al-Herz W.; Barlan I.; Baris S.; Kutukculer N.; Ochs H.D.; Plebani A. (NEW YORK75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA, 2012)
    The adaptors DOCK8 and MyD88 have been linked to serological memory. Here we report that DOCK8-deficient patients had impaired antibody responses and considerably fewer CD27+ memory B cells. B cell proliferation and ...
  • Emerging role of CD20 blockade in allogeneic hematopoietic cell transplantation 
    Kharfan-Dabaja M.A.; Bazarbachi A. (NEW YORK360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA, 2010)
    There is growing evidence incriminating B lymphocytes in the pathogenesis of graft-versus-host disease (GVHD). Better understanding of the role of B lymphocytes has uncovered new therapeutic approaches, such as CD20 blockade, ...
  • Expansion of immunoglobulin-secreting cells and defects in B cell tolerance in Rag-dependent immunodeficiency 
    Walter J.E.; Rucci F.; Patrizi L.; Recher M.; Regenass S.; Paganini T.; Keszei M.; Pessach I.; Lang P.A.; Poliani P.L.; Giliani S.; Al-Herz W.; Cowan M.J.; Puck J.M.; Bleesing J.; Niehues T.; Schuetz C.; Malech H.; DeRavin S.S.; Facchetti F.; Gennery A.R. (NEW YORK1114 FIRST AVE, 4TH FL, NEW YORK, NY 10021 USA, 2010)
    The contribution of B cells to the pathology of Omenn syndrome and leaky severe combined immunodeficiency (SCID) has not been previously investigated. We have studied a mut-mut mouse model of leaky SCID with a homozygous ...
  • Rituximab for prevention and treatment of graft-versus-host disease. 
    Kharfan-Dabaja M.A.; Cutler C.S. (TOKYO1-11-11 KUDAN-KITA, CHIYODA-KU, TOKYO, 102-0073, JAPAN, 2011)
    Growing understanding of the important role of B lymphocytes in alloreactivity has paved the way for evaluating anti-B cell therapy with rituximab in patients undergoing allogeneic hematopoietic cell transplantation. Data ...

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