Being one of the very few organs that continue to develop and differentiate late during the lifespan of an individual, the mammary gland is a good model to study how changes in the interaction between cells and their ...
The signaling pathways through which connexin (Cx) proteins, the building blocks of gap junctions (GJs), exert their tumor suppressive roles in the mammary gland remain elusive. The Wnt signaling pathways, including the ...
Gap junction intercellular communication (GJIC) is crucial for establishing coor dinated regulation of physiological processes such as proliferation, differentia tion and tissue morphogenesis. Aberrant GJIC is linked to ...
Many studies have classified cancer in the category of connexin-related pathologies. Addressing the role of connexins (Cx) in breast cancer progression has yielded contradictory results. In order to investigate the role ...
Gap junctions (GJ) are pivotal for the maintenance of cellular homeostasis, and for the modulation of a variety of developmental events. Deregulation of GJs and connexins (Cxs), the GJ forming proteins, is considered a ...
Gap junctional intercellular communication (GJIC) has been detected between metastatic tumor cells (El-sabban and Pauli, 1991) and endothelial cells. However, the role of GJIC in extravastion is poorly defined. In order ...
Breast cancer is the most common female cancer worldwide, recording high incidence rates caused by risk factors associated with urbanization and economic development. Inflammatory breast cancer (IBC) is the most lethal ...
Gap junctional intercellular communication (GJIC) is critical for tissue homeost asis and development. Deregulation of gap junctions and connexins is considered a hallmark in many cancers, including breast cancer. In this ...
In previous studies, we showed that condensed and hydrolyzable tannins can inhibit 1.2-dimethylhydrazine (DMH)-induced colon cancer in BALB-c mice when administered in drinking water, by gavage, or as intraperitoneal ...
Transcription of beta-casein gene in the mammary gland requires signals from both prolactin and BM. Recently, it was shown that cAMP enhanced gap junction communication in CID-9 mammary cells either on non-adhesive polyHEMA ...
Gap junction intercellular communication is crucial for differentiation. Connexins (Cx) are tumor suppressors, and Cx43 is often down regulated in breast tumors. Additionally, Cx43 regulates mammary tissue differentiation. ...
Differentiation of mammary epithelial cells is dependent on crucial factors such as hormones, extracellular matrix signaling and heterocellular interaction. Pr evious work in our laboratory has established a two-dimensional ...
Previous studies in our laboratory established the role of gap junctional intercellular communication in mammary epithelial cell differentiation. However, the signaling pathways downstream of GJIC leading to differentiation ...
In Previous studies, gap junctional intercellular communication (GJIC) was speculated to contribute to differentiation of mammary epithelial CID-9 cell strain (heterogeneous strain consisting of epithelial, myoepithelial ...
Beta-casein gene expression has been shown to be regulated by prolactin signalin g and cell-ECM interaction, via the JAK2-STAT5 pathway. Few studies discuss the role of GJIC in Beta-casein expression. Our lab has previously ...
In order to characterize gap junctional intercellular communication (GJIC) in the polycystic (PC) ovary, the localization and regulation of Cx43, 45, 32, and 26 in normal and PC rat ovaries was studied. Cx43 was localized ...
The role of angiogenesis in the growth and metastasis of solid tumors is well established . In fact, tumors and their surrounding accessory cells secrete angiogenic factors, predominantly VEGF and FGF. These molecules ...
Angiogenesis is the formation of vascular sprouts from preexisting blood vessel. It has been extensively studied in solid tumors. However recent reports demonstrate the occurence of angiogene is in hematological malignancies. ...
Dye transfer assays between homocellualr and heterocellular--cultures of these two cell types show functional gap junction in these two cases this--dye transfer was blocked upon application of gap junction inhibitors. ...
Previous studies in our laboratory have suggested that GJIC played an important role in mammary epithelial differentiation however, the role of homocellular and heterocellular GJIC, the specific Cx(s) involved and the ...