AUB ScholarWorks

Browsing by Subject "Ubiquitin"

Browsing by Subject "Ubiquitin"

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  • Human T cell leukemia virus type 2 tax-mediated NF-κB activation involves a mechanism independent of tax conjugation to ubiquitin and SUMO 
    Journo C.; Bonnet A.; Favre-bonvin A.; Turpin J.; Vinera J.; Cote E.; Chevalier S.A.; Kfoury Y.; Bazarbachi A.; Pique C.; Mahieux R. (WASHINGTON1752 N ST NW, WASHINGTON, DC 20036-2904 USA, 2013)
    Permanent activation of the NF-κB pathway by the human T cell leukemia virus type 1 (HTLV-1) Tax (Tax1) viral transactivator is a key event in the process of HTLV-1-induced T lymphocyte immortalization and leukemogenesis. ...
  • Low nuclear body formation and tax SUMOylation do not prevent NF-kappaB promoter activation 
    Bonnet A.; Randrianarison-Huetz V.; Nzounza P.; Nedelec M.; Chazal M.; Waast L.; Pene S.; Bazarbachi A.; Mahieux R.; Benit L.; Pique C. (LONDON236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND, 2012)
    Background: The Tax protein encoded by Human T-lymphotropic virus type 1 (HTLV-1) is a powerful activator of the NF-κB pathway, a property critical for HTLV-1-induced immortalization of CD4+ T lymphocytes. Tax permanently ...
  • Tax ubiquitylation and sumoylation control critical cytoplasmic and nuclear steps of NF-κB activation 
    Nasr R.; Chiari E.; El-Sabban M.; Mahieux R.; Kfoury Y.; Abdulhay M.; Yazbeck V.; Hermine O.; De The H.; Pique C.; Bazarbachi A. (WASHINGTON1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA, 2006)
    The Tax oncoprotein plays a crucial role in the proliferation and transformation of human T-cell leukemia virus type I (HTLV-I)-infected T lymphocytes through various mechanisms, including activation of the nuclear factor ...
  • Tax ubiquitylation and SUMOylation control the dynamic shuttling of Tax and NEMO between Ubc9 nuclear bodies and the centrosome 
    Kfoury Y.; Setterblad N.; El-Sabban M.; Zamborlini A.; Dassouki Z.; El Hajj H.; Hermine O.; Pique C.; De The H.; Saib A.; Bazarbachi A. (WASHINGTON1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA, 2011)
    The human T-lymphotropic virus type I oncoprotein Tax is critical for T-cell transformation, acting mainly through nuclear factor kappa B essential modulator (NEMO) binding and subsequent nuclear factor-κB activation. Tax ...
  • Ubiquitylated Tax targets and binds the IKK signalosome at the centrosome 
    Kfoury Y.; Nasr R.; Favre-Bonvin A.; El-Sabban M.; Renault N.; Giron M.-L.; Setterblad N.; Hajj H.E.; Chiari E.; Mikati A.G.; Hermine O.; Saib A.; De The H.; Pique C.; Bazarbachi A. (LONDONMACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND, 2008)
    Constitutive activation of the NF-κB pathway by the Tax oncoprotein plays a crucial role in the proliferation and transformation of HTLV-I infected T lymphocytes. We have previously shown that Tax ubiquitylation on C-terminal ...

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