Premeal phosphorus supplementation for reducing energy intake and body weight -

Abstract

Background:The present study is based on accumulating evidence in animals supporting an inverse relationship between eating behavior and hepatic Adenosine TriPhosphate (ATP) levels, that are known to be dependent on Phosphorous availability. In line with that, an inverse relationship between plasma phosphorus and body weight has been reported. Furthermore, common foods typically associated with weight gain, such as refined cereals, sweeteners, and oils, are low in phosphorus. Objective: Preliminary data have previously demonstrated that pre-meal Phosphorus (P) intake reduces immediate subsequent food intake by 27- 33percent. This study aims to investigate the acute effect of increasing doses of phosphorus, on satiety, and subsequent food intake in overweight-obese subjects, and the chronic effect (3 months) of phosphorus supplementation on food intake, bodyweight, waist circumference, HbA1c, insulin sensitivity and glucose tolerance of overweight and obese subjects.We hypothesize that P supplementation suppresses satiety and food intake and subsequently reduces body weight, waist circumfer4ence and HbA1c, which will improve insulin sensitivity and glucose tolerance.Such effects would be expected to reduce morbidity and mortality. Design:The study is divided into two experiments in which the acute and chronic effects of phosphorus supplementation have been studied. The acute study is a randomized crossover study. Healthy overweight-obese women (n=12) with a BMI of 31.0±1.3kg-m2and a mean age of 29.75±2.36 yearswere recruited. Subjects consumed different phosphorus or placebo (potassium phosphate or cellulose) doses with 0mg, 125mg, 250mg, 375mg, or 500mg randomly on different test days for 5 weeks with a washout out period of 1 week between test days. Visual analog scales rated hunger and satiety for 0min, 15min, 30min, 45min, 60min, 75min, and food intake was measured at an ad libitum lunch of pizza and water 80 minutes after consuming the supplements. As for the chronic effect of phosphorus, it is a dou