AUB ScholarWorks

Browsing Faculty of Medicine (FM) by Subject "B Raf kinase"

Browsing Faculty of Medicine (FM) by Subject "B Raf kinase"

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  • BRAF analysis on a spectrum of melanocytic neoplasms: An epidemiological study across differing UV regions 
    Saroufim M.; Habib R.; Karram S.; Youssef Massad C.; Taraif S.; Loya A.; Houreih M.A.; Sheikh S.S.; Amr S.S.; Satti M.; Oberkanins C.; Khalifeh I. (PHILADELPHIA530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA, 2014)
    BRAF mutation has been linked to the development of melanocytic tumors in homogeneous Caucasian cohorts. The role of solar UV radiation (UVR) in BRAF mutation status is poorly understood. We studied the epidemiology of ...
  • BRAF mutational epidemiology in dysplastic nevi: Does different solar UV radiation exposure matter? 
    Saroufim M.; Novy M.; Taraif S.; Habib R.H.; Loya A.; Rauscher B.; Kriegshauser G.; Oberkanins C.; Khalifeh I. (Blackwell Publishing Ltd; HOBOKEN111 RIVER ST, HOBOKEN 07030-5774, NJ USA, 2014)
    Background Proto-oncogene B-Raf (BRAF) mutation rates have been reported in nevi and melanomas of homogeneous Caucasian cohorts. Objective To study the demographics of BRAF mutations in dysplastic nevi of populations with ...
  • Controversies in the management and followup of differentiated thyroid cancer: Beyond the guidelines 
    Ahmadieh H.; Azar S.T. (, 2012)
    Thyroid cancer is among the most common endocrine malignancies. Genetic and environmental factors play an important role in the pathogenesis of differentiated thyroid cancer. Both have good prognosis but with frequent ...
  • Cutaneous malignant melanoma: Update on diagnostic and prognostic biomarkers 
    Abbas O.; Miller D.D.; Bhawan J. (Lippincott Williams and Wilkins; PHILADELPHIA530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA, 2014)
    The incidence of cutaneous malignant melanoma has rapidly increased in recent years in all parts of the world, and melanoma is a leading cause of cancer death. As even relatively small melanomas may have metastatic potential, ...
  • Metformin in dermatology: An overview 
    Badr D.; Kurban M.; Abbas O. (HOBOKEN111 RIVER ST, HOBOKEN 07030-5774, NJ USA, 2013)
    For several decades, metformin has been used as an oral hypoglycaemic agent, where it is the first line of treatment in overweight and obese type 2 diabetic patients. This is because it decreases the hepatic glucose output ...
  • Methods of overcoming treatment resistance in colorectal cancer 
    Temraz S.; Mukherji D.; Alameddine R.; Shamseddine A. (NEW YORK360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA, 2014)
    Metastatic colorectal cancer remains a lethal disease with a poor prognosis in the majority of patients. Multiple drug combinations have been developed in recent years that have significantly improved response rates and ...
  • Mutation of IGFBP7 causes upregulation of BRAF-MEK-ERK pathway and familial retinal arterial macroaneurysms 
    Abu-Safieh L.; Abboud E.B.; Alkuraya H.; Shamseldin H.; Al-Enzi S.; Al-Abdi L.; Hashem M.; Colak D.; Jarallah A.; Ahmad H.; Bobis S.; Nemer G.; Bitar F.; Alkuraya F.S. (CAMBRIDGE600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA, 2011)
    Insulin-like growth factor binding proteins (IGFBPs) play important physiological functions through the modulation of IGF signaling as well as IGF-independent mechanisms. Despite the established role of IGFs in development, ...
  • Predictors of BRAF mutation in melanocytic nevi: Analysis across regions with different UV radiation exposure 
    Karram S.; Novy M.; Saroufim M.; Loya A.; Taraif S.; Houreih M.A.; Rauscher B.; Habib R.H.; Oberkanins C.; Khalifeh I. (PHILADELPHIA530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA, 2013)
    BACKGROUND:: BRAF mutations have been implicated in initiating promutagenic cellular melanocytic proliferation mostly based on homogeneous Western-based cohorts. Data addressing the possible interaction between exposure ...

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