Browsing Faculty of Medicine (FM) by Subject "T lymphocyte activation"

Now showing items 1-9 of 9

Calcineurin inhibitors: 40 Years later, can't live without...

Azzi J.R.; Sayegh M.H.; Mallat S.G. (BETHESDA9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA, 2013)

Calcineurin inhibitors (CNIs) revolutionized the field of organ transplantation and remain the standard of care 40 years after the discovery of cyclosporine. The early impressive results of cyclosporine in kidney transplant ...
EAPB0203, a member of the imidazoquinoxaline family, inhibits growth and induces caspase-dependent apoptosis in T-cell lymphomas and HTLV-I associated adult T-cell leukemia-lymphoma

Moarbess G.; El-Hajj H.; Kfoury Y.; El-Sabban M.E.; Lepelletier Y.; Hermine O.; Deleuze-Masquefa C.; Bonnet P.-A.; Bazarbachi A. (WASHINGTON1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA, 2008)

Imiquimod is an immune response modifier currently used as a topical treatment of genital warts, basal cell carcinoma, cutaneous metastasis of malignant melanoma, and vascular tumors. We developed more efficient killers ...
Efficacy and mechanism of action of the proteasome inhibitor PS-341 in T-cell lymphomas and HTLV-I associated adult T-cell leukemia-lymphoma

Nasr R.; El-Sabban M.E.; Karam J.-A.; Dbaibo G.; Kfoury Y.; Arnulf B.; Lepelletier Y.; Bex F.; De The H.; Hermine O.; Bazarbachi A. (LONDONMACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND, 2005)

HTLV-I associated adult T-cell leukemia (ATL) and HTLV-I-negative peripheral T-cell lymphomas are associated with poor prognosis. Using pharmacological concentrations of the proteasome inhibitor PS-341, we demonstrate ...
IL-4 and retinoic acid synergistically induce regulatory dendritic cells expressing Aldh1a2

Zhu B.; Buttrick T.; Bassil R.; Zhu C.; Olah M.; Wu C.; Xiao S.; Orent W.; Elyaman W.; Khoury S.J. (BETHESDA9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA, 2013)

Although activated inflammatory monocytes (IMCs) and inflammatory dendritic cells (IDCs) are potent T cell suppressors, nonactivated IMCs and IDCs promote T cell activation and Th1-Th17 cell differentiation. In this study, ...
Inhibition of mammalian target of rapamycin signaling by everolimus induces senescence in adult T-cell leukemia-lymphoma and apoptosis in peripheral T-cell lymphomas

Darwiche N.; Sinjab A.; Abou-Lteif G.; Chedid M.B.; Hermine O.; Dbaibo G.; Bazarbachi A. (MALDENCOMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA, 2011)

HTLV-I-associated adult T-cell leukemia-lymphoma (ATL) and human T-cell lymphotropic virus type I (HTLV-I)-negative peripheral T-cell lymphomas carry poor prognosis mainly because of acquired resistance to chemotherapy. ...
New therapeutic approaches for adult T-cell leukaemia

Bazarbachi A.; Ghez D.; Lepelletier Y.; Nasr R.; de The H.; El-Sabban M.E.; Hermine O. (LONDON84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND, 2004)

Adult T-cell leukaemia or lymphoma is an aggressive malignant disease of mature activated T cells caused by human T-cell lymphotropic virus type I. Patients with this disease have a very poor outlook because of intrinsic ...
Patented small molecules against psoriasis

Abdelnoor A.M. (LONDONTELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND, 2009)

Background: It is hypothesized that psoriasis is an autoimmune disease. The most recent therapeutic approach that proved to be more effective than earlier methods of treatment is the use of mAb-fusion proteins. Efforts ...
T-cell co-stimulatory blockade in transplantation: Two steps forward one step back!

Riella L.V.; Sayegh M.H. (LONDONTELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND, 2013)

Introduction: The concern about nephrotoxicity with calcineurin inhibitors led to the search of novel agents for immunosuppression. Based on the requirement of T-cell co-stimulatory signals to fully activated naïve T cells, ...
Targeting CD28 to prevent transplant rejection

Yeung M.Y.; Najafian N.; Sayegh M.H. (LONDONTELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND, 2014)

Introduction: The pivotal role of costimulatory pathways in regulating T-cell activation versus tolerance has stimulated tremendous interest in their manipulation for therapeutic purposes. Of these, the CD28-B7 pathway is ...

Now showing items 1-9 of 9

Search AUB ScholarWorks

Browse

All of AUB ScholarWorks
This Community
- By Issue Date
- Authors
- Titles
- Subjects

My Account

Copyright Statement

All materials included in the institutional repository are protected by copyright laws and are the property of their respective copyright holders. Materials may be used for non-commercial, educational, or research purposes only, and must be cited or attributed to the original source. Permission for any other use must be obtained from the copyright holder(s) directly. The American University of Beirut Libraries does not assume responsibility for any infringement of copyright laws that may occur as a result of the use of materials in the repository. If you believe that your copyright has been infringed upon in the repository, please contact the AUB Libraries immediately.

For further information, please contact us at scholarworks@aub.edu.lb

Browsing Faculty of Medicine (FM) by Subject "T lymphocyte activation"

Browsing Faculty of Medicine (FM) by Subject "T lymphocyte activation"

Search AUB ScholarWorks

Browse

All of AUB ScholarWorks

This Community

My Account

Copyright Statement