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Browsing Pathology and Laboratory Medicine by Title

Now showing items 107-126 of 389

EAPB0503: An Imiquimod analog with potent in vitro activity against cutaneous leishmaniasis caused by Leishmania major and Leishmania tropica

El Hajj, Rana H.; Bou Youness, Hanady; Lachaud, Laurence; Bastien, Patrick; Masquefa, Carine; Bonnet, Pierre Antoine; El-Hajj, Hiba Ahmad; Khalifeh, Ibrahim M. (Public Library of Science, 2018)

Cutaneous Leishmaniasis (CL) is a parasitic infection classified by the WHO as one of the most uncontrolled spreading neglected diseases. Syria is endemic for Leishmania tropica and Leishmania major, causing CL in the ...
Effect of the mode of application of cryopreserved human amniotic membrane on adhesion formation after abdomino pelvic surgery in a mouse model

Nassif, Joseph A.; Abbasi, Sehrish A.; Kechli, Mohamad Karim; Boutary, Suzan S.; Ghulmiyyah, Labib M.; Khalifeh, Ibrahim M.; Ghaddara, Hussein Abou; Nassar, Anwar H. (Frontiers Media S.A., 2016)

Adhesions after abdomino-pelvic surgery are a cause of morbidity and reoperations. The use of human amniotic membrane (HAM) for adhesion prevention has given controversial results. The mode of administration of the amniotic ...
Effect of vitamin D replacement on immunological biomarkers in patients with multiple sclerosis

Mrad, May F.; El-Ayoubi, Nabil K.; Esmerian, Maria O.; Kazan, Jalal M.; Khoury, Samia J. (Academic Press Inc., 2017)

We aimed to investigate the immunologic effects of vitamin D replacement in RRMS patients. In a controlled single center study, patients deficient in 25-hydroxyvitamin D (serum level < 25 ng/ml) received 10,000 IU/week ...
Effective targeting of chronic myeloid leukemia initiating activity with the combination of arsenic trioxide and interferon alpha

El-Eit, Rabab M.; Iskandarani, Ahmad N.; Saliba, Jessica L.; Jabbour, Mark N.; Mahfouz, Rami A.R.; Bitar, Nizar M.A.; El-Ayoubi, Hanadi Rafii; Zaatari, Ghazi S.; Mahon, François Xavier; de Thȩ, Hugues B.; Bazarbachi, Ali Abdul Hamid; Nasr, Rihab R. (2014)

Imatinib is the standard of care in chronic meloid leukemia (CML) therapy. However, imatinib is not curative since most patients who discontinue therapy relapse indicating that leukemia initiating cells (LIC) are resistant. ...
Effectiveness of the quadrivalent inactivated influenza vaccine in Japan during the 2015–2016 season: A test-negative case-control study comparing the results by real time PCR, virus isolation

Chon, Irina; Saito, Reiko; Hibino, Akinobu; Yagami, Ren; Dapat, Clyde P.; Odagiri, Takashi; Kondo, Hiroshi; Sato, Isamu; Kimura, Shinji; Kawashima, Takashi; Kodo, Naoki; Masaki, Hironori; Asoh, Norichika; Tsuchihashi, Yoshiko; Zaraket, Hassan; Shobugawa, Yugo (Elsevier Ltd, 2019)

Background: We estimated influenza vaccine effectiveness (VE) in 2015–2016 season against medically attended, laboratory-confirmed influenza, when quadrivalent inactivated vaccine (IIV4) was first introduced in Japan, using ...
Effects of exendin-4 and selenium on the expression of GLP-1R, IRS-1, and preproinsulin in the pancreas of diabetic rats

Barakat, Ghinwa M.; Moustafa, Mohamed E.; Khalifeh, Ibrahim M.; Hodroj, Mohammad Hassan; Bikhazi, Anwar B.; Rizk, Sandra E. (Springer Netherlands, 2016)

The mechanisms by which exendin-4 and selenium exert their antidiabetic actions are still unclear. Here, we investigated the effects of exendin-4 or selenium administration on the expression of glucagon-like peptide-1 ...
Efficacy and safety-in analysis of short-course radiation followed by mFOLFOX-6 plus avelumab for locally advanced rectal adenocarcinoma

Shamseddine, Ali I.; Zeidan, Youssef H.; el-Husseini, Ziad; Kreidieh, Malek; Al Darazi, Monita; Turfa, Rim; Kattan, Joseph G.; Khalifeh, Ibrahim M.; Mukherji, Deborah M.; Temraz, Sally N.; Alqasem, Kholoud Saleh; Amarin, Rula; Al Awabdeh, Tala; Deeba, Samer; Jamali, Faek R.; Mohamad, Issa A.; El-Khaldi, Mousa; Daoud, Faiez S.; Al-Masri, Mahmoud M.; Dabous, Ali; Hushki, Ahmad; Jaber, Omar Issa; Charafeddine, Maya A.; Geara, Fady B. (BioMed Central Ltd, 2020)

Background: Neoadjuvant chemotherapy and short-course radiotherapy followed by resection has been gaining recognition in the treatment of rectal cancer. Avelumab is a fully human immunoglobulin that binds Programmed ...
Egfr as a clinical marker in glioblastomas and other gliomas

Saadeh, Fadi S.; Mahfouz, Rami A.R.; Assi, Hazem I. (SAGE Publications Ltd, 2018)

Epidermal growth factor receptor (EGFR) is a transmembrane glycoprotein and a member of the tyrosine kinase superfamily receptor. Gliomas are tumors originating from glial cells, which show a range of aggressiveness depending ...
Emergence of Mycobacterium simiae: A retrospective study from a tertiary care center in Lebanon

Hamieh, Amal; Tayyar, Ralph; Tabaja, Hussam Z.; Zein, Saeed El; Bou-Khalil, Pierre; Kara, Nathalie; Kanafani, Zeina A.; Kanj, Nadim A.; Bou-Akl, Imad J.; Araj, George F.; Berjawi, Ghina A.; Kanj, Souha S. (Public Library of Science, 2018)

Objective The objective of this study is to describe the clinical significance of Mycobacterium simiae at a major tertiary care center in Lebanon. Methods This is a retrospective study of patients with positive cultures ...
EMT markers in locally-advanced prostate cancer: Predicting recurrence?

Cheaito, Katia A.; Bahmad, Hisham F.; Hadadeh, Ola; Saleh, Eman; Dagher, Christelle; Hammoud, Miza Salim; Shahait, Mohammed; Mrad, Zaki Abou; Nassif, I. Samer; Tawil, Ayman N.; Bulbul, Muhammad Ahmad; Khauli, Raja Bahjat; Wazzan, Wassim C.; Nasr, Rami Wajih; Shamseddine, Ali I.; Temraz, Sally N.; El-Sabban, Marwan E.; El Hajj, Albert Elias; Mukherji, Deborah M.; Abou-Kheir, Wassim G. (Frontiers Media S.A., 2019)

Background: Prostate cancer (PCa) is the second most frequent cause of cancer-related death in men worldwide. It is a heterogeneous disease at molecular and clinical levels which makes its prognosis and treatment outcome ...
Epidemiology and clinical characteristics of viral infections in hospitalized children and adolescents with cancer in Lebanon

Chamseddine, Sarah; Chmaisse, Ahmad; Akel, Imad S.; Zein, Zeinab El; Khalil, Suzan; Raad, Sarah Abi; Khati, Antoine; Ghandour, Hiba Z.; Khafaja, Sarah A.; Haj, Magda; Abboud, Miguel Raul; Mahfouz, Rami A.R.; Araj, George F.; Zaraket, Hassan; Hanna-Wakim, Rima H.; Muwakkit, Samar A.; Dbaibo, Ghassan S. (Public Library of Science, 2020)

Background Viral infections in children and adolescents with malignancy are commonly encountered and have a significant impact on morbidity and mortality. Studies and epidemiological data regarding viral infections in ...
Epidemiology, clinical manifestations, and molecular typing of salmonella typhi isolated from patients with typhoid fever in Lebanon

Kanj, Souha S.; Kanafani, Zeina A.; Shehab, Marwa; Sidani, Nisreen; Baban, Tania A.; Baltajian, Kedak; Dakdouki, Ghenwa K.; Zaatari, Mohamad; Araj, George F.; Hanna-Wakim, Rima H.; Dbaibo, Ghassan S.; Matar, Ghassan (Elsevier Ltd, 2015)

The objective of this study was to examine the epidemiology and the clinical manifestations of typhoid fever as well as the susceptibility and strain relatedness of Salmonella typhi isolates in Lebanon from 2006 to 2007. ...
Epidermal growth factor receptor (EGFR) in the era of Precision Medicine: The tale of a perfect example of targeted therapy. A review

Haddad, Joseph; Slika, Silva; Mahfouz, Rami A.R. (Elsevier B.V., 2017)

Epidermal growth factor receptor has been under the lights for the past few years as a perfect and typical example of a success story of targeted therapy. In the era of Precision Medicine, such modalities of treatment are ...
Epidermal growth factor receptor and KRAS mutations in lung adenocarcinoma: A retrospective study of the Lebanese population

Fakhruddin, Najla; Mahfouz, Rami A.R.; Farhat, Fadi Sami; Tfayli, Arafat Hussein; Abdelkhalik, Rabab; Jabbour, Mark N.; Yehia, Lamis; Mahfoud, Ziyad R.; Zaatari, Ghazi S. (Spandidos Publications, 2014)

Molecular genetic analysis of epidermal growth factor receptor (EGFR) and Kirsten rat sarcoma viral oncogene (KRAS) mutations in lung adenocarcinoma has become an integral part of lung cancer diagnosis and treatment; ...
Erythropoietic protoporphyria a clinical and molecular study from Lebanon: Ferrochelatase a potential tumor suppressor gene in colon cancer

Kadara, Humam N.; Nemer, Georges M.; Safi, Rémi; Rebeiz, Nelly; Daou, Laetitia; Delbani, D.; Btadini, Waed; Abbas, Ossama M.; Tofaili, Mona; Bitar, Fadi Fouad; Kibbi, Abdul Ghani M.; Shimomura, Yutaka; Kurban, Mazen S. (Blackwell Publishing Ltd, 2017)

Erythropoietic protoporphyria (EPP) is a rare cutaneous and systemic disease caused by mutations in the ferrochelatase gene (FECH). The molecular underpinnings of EPP in Middle Eastern populations and relative to other ...
Esophageal Cytomegalovirus and Herpes Simplex virus co-infection in an immunocompromised patient: Case report and review of literature

Bannoura, Sami; Barada, Kassem A.; Sinno, Sara A.J.; Boulos, Fouad I.; Chakhachiro, Zaher I. (Elsevier Ltd, 2020)

Herpes simplex virus and Cytomegalovirus co-infection has been reported to occur in a variety of sites in immunocompromised patients. To our knowledge, few cases of such co-infection have been reported to occur in the ...
Establishment and characterization of prostate organoids from treatment-naïve patients with prostate cancer

Cheaito, Katia A.; Bahmad, Hisham F.; Hadadeh, Ola; Msheik, Hiba; Monzer, Alissar; Ballout, Farah; Dagher, Christelle; Telvizian, Talar; Saheb, Nour; Tawil, Ayman N.; El-Sabban, Marwan E.; El Hajj, Albert Elias; Mukherji, Deborah M.; Al-Sayegh, Mohamed Ahmed; Abou-Kheir, Wassim G. (Spandidos Publications, 2022)

Three-dimensional (3D) organoid culture systems are emerging as potential reliable tools to investigate basic developmental processes of human disease, especially cancer. The present study used established and modified ...
Estrogen receptor α is not a candidate gene for metabolic syndrome in Caucasian elderly subjects

Hoteit, M.; Arabi, Asma; Habib, Robert H.; Mahfouz, Rami A.R.; Baddoura, Rafic M.; Halaby, Georges H.; El-Hajj Fuleihan, Ghada A. (2014)

Objective Variants of estrogen receptor α (ERα) have been associated with obesity, dyslipidemia, diabetes and blood pressure. The Middle East registers some of the highest rate of metabolic syndrome worldwide. The aim of ...
Evaluating the efficacies of carbapenem/β-lactamase inhibitors against carbapenem-resistant gram-negative bacteria in vitro and in vivo

El Hafi, Bassam; Rasheed, Sari Shawki; Abou Fayad, Antoine G.; Araj, George F.; Matar, Ghassan (Frontiers Media S.A., 2019)

Background: Carbapenem-resistant Gram-negative bacteria are a major clinical concern as they cause virtually untreatable infections since carbapenems are among the last-resort antimicrobial agents. β-Lactamases implicated ...
Evaluation of antibiotics pack size compliance with the treatment guidelines for community-acquired pneumonia and urinary tract infections in the Lebanese population

Koubaitary, Shafika; Fawaz, Mirna A.; Al Khatib, Alissar (Taylor and Francis Ltd., 2021)

Antibiotic resistance emergence has contributed to global public health threat rendering the choices of antibiotics limited. Antibiotics are universally packaged by manufacturers without taking into consideration scientific ...

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Browsing Pathology and Laboratory Medicine by Title

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