AUB ScholarWorks

Browsing Biochemistry and Molecular Genetics by Issue Date

Browsing Biochemistry and Molecular Genetics by Issue Date

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  • Mouhieddine, Tarek H.; Kobeissy, Firas H.; Itani, Muhieddine M.; Nokkari, Amaly; Wang, Kevin Ka Wang (Editorial Board of Neural Regeneration Research, 2014)
    The prevalence of neurodegenerative diseases and neural injury disorders is increasing worldwide. Research is now focusing on improving current neurogenesis techniques including neural stem cell therapy and other biochemical ...
  • Shaib, Houssam A.; Cochet, Nelly; Ribeiro, Thierry; Abdel Nour, Afif M.; Nemer, Georges M.; Azhar, Esam Ibraheem; Iyer, Archana P.; Kumosani, Taha Abdullah; Harakeh, Steve Mustapha; Barbour, Elie K. (Journal of Infection in Developing Countries, 2014)
    Introduction: Avian influenza viruses of the H9N2 subtype have been reported to cause human infections. This study demonstrates the impact of nasal viral passaging of avian H9N2 in hamsters on its cross species-pathogenic ...
  • Fahed, Akl C.; Habib, Robert H.; Nemer, Georges M.; Azar, Sami T.; Andary, Rabih R.; Arabi, Mariam Toufic; Moubarak, Elie M.; Bitar, Fadi Fouad; Haddad, Fady F. (2014)
    Background Intima-media thickness (IMT) is a well-described marker of cardiovascular disease. In this study we aim to determine whether low-density lipoprotein (LDL) levels and disease-related mutation status can predict ...
  • Shibbani, Kamel; Fahed, Akl C.; Al-Shaar, Laila; Arabi, Mariam Toufic; Nemer, Georges M.; Bitar, Fadi Fouad; Majdalani, Marianne Nimah (2014)
    Solute carrier family 22 member 5 (SLC22A5) encodes a sodium-dependent ion transporter responsible for shuffling carnitine across the plasma membrane. This process provides energy for the heart, among other organs allowing ...
  • Husari, Ahmad W.; Khayat, Aline; Bitar, Hala; Hashem, Yasmine; Rizkallah, Alain; Zaatari, Ghazi S.; El-Sabban, Marwan E. (BioMed Central Ltd., 2014)
    Background: Hyperoxia triggers the release of toxic reactive oxygen species (ROS). Pomegranate Juice (PJ) is a rich source of potent antioxidants. We assessed the effects of PJ supplementation on Acute Lung Injury (ALI) ...
  • Hasan, Anwarul Ul; Nurunnabi, Md; Morshed, Mahboob; Paul, Arghya; Polini, Alessandro; Kuila, Tapas; Al Hariri, Moustafa; Lee, Yong-kyu; Jaffa, Ayad A. (Hindawi Publishing Corporation, 2014)
    Biosensors research is a fast growing field in which tens of thousands of papers have been published over the years, and the industry is now worth billions of dollars. The biosensor products have found their applications ...
  • Kobeissy, Firas H.; Mouhieddine, Tarek H.; Nokkari, Amaly; Itani, Muhieddine M.; Mouhieddine, Mohamed; Zhang, Zhiqun; Zhu, Rui; Gold, Mark S.; Wang, Kevin Ka Wang; Mechref, Yehia S. (Elsevier B.V., 2014)
    Currently, drug abuse and addiction represent a global public health concern with about 13.6 million people using illicit drugs in the USA alone. Substance abuse intervenes in normal brain functioning, causing alterations ...
  • Pagliaccia, Francesca; Habib, Aida A.; Pitocco, Dario; Petrucci, Giovanna; Zaccardi, Francesco; Di Stasio, Enrico; Rocca, Bianca (2014)
    Background: Thromboxane (TX) A2 is a pro-thrombotic prostanoid synthesized by activated platelets, biotransformed into 11-dehydro-TXB 2, measurable in urines. Eleven-dehydro-TXB2 excretion is increased in high risk ...
  • Mondello, Stefania; Büki, Andràs; Barzó, Pál; Randall, Jeffrey D.; Provuncher, Gail K.; Hanlon, David W.; Wilson, David H.; Kobeissy, Firas H.; Jeromin, Andreas (Nature Publishing Group, 2014)
    The role of amyloid-β (Aβ) neuropathology and its significant changes in biofluids after traumatic brain injury (TBI) is still debated. We used ultrasensitive digital ELISA approach to assess amyloid-β1-42 (Aβ42) concentrations ...
  • Gali-Muhtasib, Hala Uthman; Hmadi, Raed A.; Kareh, Mike; Tohme, Rita; Darwiche, Nadine D. (Springer New York LLC, 2015)
    Despite remarkable progress in the discovery and development of novel cancer therapeutics, cancer remains the second leading cause of death in the world. For many years, compounds derived from plants have been at the ...
  • Makoukji, Joelle; Raad, Mohamad A.; Genadry, Katia Christina; El-Sitt, Sally Boulos; Makhoul, Nadine J.; Saad Aldin, Ehab; Nohra, Eden A.; Jabbour, Mark N.; Sangaralingam, Ajanthah; Chelala, Claude; Habib, Robert H.; Boulos, Fouad I.; Tfayli, Arafat Hussein; Boustany, Rose Mary Naaman (Frontiers Media S.A., 2015)
    Breast cancer is the most common cancer in women worldwide. Elucidation of underlying biology and molecular pathways is necessary for improving therapeutic options and clinical outcomes. CLN3 protein (CLN3p), deficient in ...
  • Hanna-Wakim, Rima H.; Ghanem, Soha T.; El Helou, Mona W.; Khafaja, Sarah A.; Shaker, Rouba A.; Hassan, Sara A.; Saad, Randa K.; Hedari, Carine P.; Khinkarly, Rima W.; Hajar, Farah M.; Bakhash, Marwan; El Karah, Dima; Akel, Imad S.; Rajab, Mariam El; Khoury, Mireille Lteif; Dbaibo, Ghassan S. (Frontiers Research Foundation, 2015)
    Background: Urinary tract infections (UTIs) are among the most common infections in the pediatric population. Over the last two decades, antibiotic resistance is increasing significantly as extended spectrum beta lactamase ...
  • Abou-Hassan, Ossama K.; Fahed, Akl C.; Batrawi, Manal; Arabi, Mariam Toufic; Refaat, Marwan M.; DePalma, Steven R.; Seidman, Jonathan G.; Seidman, Christine E.; Bitar, Fadi Fouad; Nemer, Georges M. (Nature Publishing Group, 2015)
    NKX2-5 mutations are associated with different forms of congenital heart disease. Despite the knowledge gained from molecular and animal studies, genotype-phenotype correlations in humans are limited by the lack of large ...
  • Hage-Sleiman, Rouba; Hamze, Asmaa B.; Reslan, Lina; Kobeissy, Hadile; Dbaibo, Ghassan S. (Hindawi Limited, 2015)
    The protein kinases C (PKCs) are a family of serine/threonine kinases involved in regulating multiple essential cellular processes such as survival, proliferation, and differentiation. Of particular interest is the novel, ...
  • El Zein, Ola; Usta, Julnar A.R.; El Moussawi, Layla; Kreydiyyeh, Sawsan Ibrahim (Elsevier Inc., 2015)
    We demonstrated previously an inhibitory effect of luminal leptin on glucose absorption in differentiated Caco-2 cells. Since this process is dependent on the Na+ gradient established by the Na+/K+ATPase this work was ...
  • Refaat, Marwan M.; Hotait, Mostafa; London, Barry (Current Medicine Group LLC 1, 2015)
    Sudden cardiac death (SCD) is defined by the World Health Organization (WHO) as death within 1 h of symptom onset (witnessed) or within 24 h of being observed alive and symptom free (unwitnessed). It affects more than ...
  • Poulsen, Kristian Lundgaard; Hotait, Mostafa; Calloe, Kirstine; Klaerke, Dan Arne; Rebeiz, Abdallah G.; Nemer, Georges M.; Tejada, Maria De Los Angeles; Refaat, Marwan M. (Blackwell Publishing Inc., 2015)
    Background Loss-of-function mutations in the voltage gated potassium channel Kv11.1 have been associated with the Long QT Syndrome (LQTS) type 2. We identified the p.T613A mutation in Kv11.1 in a family with LQTS. T613A ...
  • Alawieh, Ali Mostafa; Mondello, Stefania; Kobeissy, Firas H.; Shibbani, Kamel; Bassim, Marc Kaissar (Expert Reviews Ltd., 2015)
    Although proteomics has been exploited in a wide range of diseases for identification of biomarkers and pathophysiological mechanisms, there are still biomedical disciplines such as otology where proteomics platforms are ...
  • Duhamel, Marie; Rodet, Franck; Delhem, Nadira; Vanden-Abeele, Fabien; Kobeissy, Firas H.; Nataf, Serge; Pays, Laurent; Desjardins, Roxane; Gagnon, Hugo; Wisztorski, Maxence; Fournier, Isabelle; Day, Robert; SALZET, Michel (American Society for Biochemistry and Molecular Biology Inc., 2015)
    Macrophages provide the first line of host immune defense. Their activation triggers the secretion of pro-inflammatory cytokines and chemokines recruiting other immune cells. In cancer, macrophages present an M2 anti-inflammatory ...
  • El-Achkar, Ghewa A.; Jouni, Mariam; Mrad, May F.; Hirz, Taghreed; El Hachem, Nehme; Khalaf, Ali Ali; Hammoud, Soukaina; Fayyad-kazan, Hussein; Eid, Assaad A.; Badran, Bassam M.; Abou-Merhi, Raghida; Hachem, Ali; Hamade, Eva; Habib, Aida A. (Elsevier, 2015)
    Cyclooxygenases (COXs) are important membrane-bound heme containing enzymes important in platelet activation and inflammation. COX-1 is constitutively expressed in most cells whereas COX-2 is an inducible isoform highly ...

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