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Browsing Biochemistry and Molecular Genetics - Faculty Publications by Issue Date

Now showing items 1-20 of 51

Immunodiagnosis of Prune dwarf virus using antiserum produced to its recombinant coat protein

Abou-Jawdah Y.; Sobh H.; Cordahi N.; Kawtharani H.; Nemer G.; Maxwell D.P.; Nakhla M.K. (AMSTERDAMPO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS, 2004)

Certification represents the first line of defense against fruit tree viruses. For certification or surveys dealing with large number of samples, ELISA is still considered the technique of choice and requires a continuous ...
Decreased hephaestin activity in the intestine of Copper-deficient mice causes systemic iron deficiency

Chen H.; Huang G.; Su T.; Gao H.; Attieh Z.K.; McKie A.T.; Anderson G.J.; Vulpe C.D. (BETHESDA9650 ROCKVILLE PIKE, RM L-2407A, BETHESDA, MD 20814 USA, 2006)

Copper and iron metabolism intersect in mammals. Copper deficiency simultaneously leads to decreased iron levels in some tissues and iron deficiency anemia, whereas it results in iron overload in other tissues such as the ...
A novel mutation in the GATA4 gene in patients with Tetralogy of Fallot.

Nemer G.; Fadlalah F.; Usta J.; Nemer M.; Dbaibo G.; Obeid M.; Bitar F. (, 2006)

In vertebrates, heart formation which integrates different structures and cell types is a complex process that involves a network of genes regulated by transcription factors. Proper spatiotemporal expression of these factors ...
The omega-3 fatty acid docosahexaenoate attenuates endothelial cyclooxygenase-2 induction through both NADP(H) oxidase and PKCε inhibition

Massaro M.; Habib A.; Lubrano L.; Del Turco S.; Lazzerini G.; Bourcier T.; Weksler B.B.; De Caterina R. (WASHINGTON2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA, 2006)

A high intake of the omega-3 fatty acid docosahexaenoate [docosahexaenoic acid (DHA)] has been associated with systemic antiinflammatory effects and cardiovascular protection. Cyclooxygenase (COX)-2 is responsible for the ...
The Kruppel-like transcription factor KLF13 is a novel regulator of heart development

Lavallee G.; Andelfinger G.; Nadeau M.; Lefebvre C.; Nemer G.; Horb M.E.; Nemer M. (, 2006)

In humans, congenital heart defects occur in 1-2percent of live birth, but the molecular mechanisms and causative genes remain unidentified in the majority of cases. We have uncovered a novel transcription pathway important ...
Erratum: The omega-3 fatty acid docosahexaenoate attenuates endothelial cyclooxygenase-2 induction through both NADP(H) oxidase and PKCε inhibition (Proceedings of the National Academy of Sciences of the United States of America (2006) 103, 41, (15184-15189) DOI: 10.1073-pnas.0510086103)

Massaro M.; Habib A.; Lubrano L.; Del Turco S.; Lazzerini G.; Bourcier T.; Weksler B.B.; De Caterina R. (WASHINGTON2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA, 2007)

[No abstract available]
A 23-year-old man with seizures and visual deficit

Boustany R.-M.; Britton J.W.; Parisi J.E.; Keegan B.M. (PHILADELPHIA530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA, 2008)

[No abstract available]
CLN3p impacts galactosylceramide transport, raft morphology, and lipid content

Rusyn E.; Mousallem T.; Persaud-Sawin D.-A.; Miller S.; Boustany R.-M.N. (BALTIMORE351 W CAMDEN ST, BALTIMORE, MD 21201-2436 USA, 2008)

Juvenile neuronal ceroid lipofuscinosis (JNCL) belongs to the neuronal ceroid lipofuscinoses characterized by blindness-seizures-motor-cognitive decline and early death. JNCL is caused by CLN3 gene mutations that negatively ...
Efficacy and molecular studies of a Lebanese isolate of Beauveria for control of Thaumetopoea wilkinsoni (Lepidoptera: Thaumetopoeidae)

Abou-Jawdah Y.; Atamian H.; Nemer G.; Kfoury L.; Choukrallah N.; Hanna L.; Nemer N. (ABINGDON4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND, 2008)

A Lebanese isolate of a Beauveria species originally isolated from a hymenopterous insect pest was found to be very effective against the pine processionary moth Thaumetopoea wilkinsoni. In laboratory bioassays, high ...
Distinct expression and function of alternatively spliced Tbx5 isoforms in cell growth and differentiation

Georges R.; Nemer G.; Morin M.; Lefebvre C.; Nemer M. (, 2008)

Mutations in the T-box transcription factor Tbx5 cause Holt-Oram syndrome, an autosomal dominant disease characterized by a wide spectrum of cardiac and upper limb defects with variable expressivity. Tbx5 haploinsufficiency ...
Copper-adenine complex, a compound, with multi-biochemical targets and potential anti-cancer effect

Hammud H.H.; Nemer G.; Sawma W.; Touma J.; Barnabe P.; Bou-Mouglabey Y.; Ghannoum A.; El-Hajjar J.; Usta J. (CLAREELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND, 2008)

A series of adenine-copper complexes (1-6) with various ligands (Cl-, SCN-, BF4- and acac [acetylacetonate ion]) have been synthesized and characterized by elemental analysis, infrared spectroscopy and thermal analysis. ...
Platelet Cyclooxygenase Inhibition by Low-Dose Aspirin Is Not Reflected Consistently by Platelet Function Assays. Implications for Aspirin Resistance

Santilli F.; Rocca B.; De Cristofaro R.; Lattanzio S.; Pietrangelo L.; Habib A.; Pettinella C.; Recchiuti A.; Ferrante E.; Ciabattoni G.; Davi G.; Patrono C. (NEW YORK360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA, 2009)

Objective: This study was conducted to assess the thromboxane (TX) dependence of biochemical and functional indexes used to monitor the effect of low-dose aspirin. Background: Functional assays of the antiplatelet effects ...
GATA4 in Heart Development and Disease

Nemer G.; Nemer M. (Elsevier Inc.;, 2010)

This chapter discusses the role of GATA4 in the heart development and disease. GATA proteins are expressed in a cell- and temporal-specific manner. Their essential roles in early development are well established and include ...
Impact of synergism of calcium phosphomycin-tylosin tartarate supplements on the performance of broilers in the Lebanon [Impatto di una somministrazione sinergica degli integratori fosfomicina calcica e tilosina tartrato sulle prestazioni di pulcini di broiler in libano]

Barbour E.K.; El-Hajj Z.; Shaib H.; Itani H.; Saadeh M.; Haidar W.; Jaber L.; Demloj R.; Harakeh S. (, 2010)

Summary The authors evaluate the impact of a synergistic preparation (SP) of supplements (a combination of calcium phosphomycin and tylosine tartarate) on the performance of broilers with a history of carcass condemnation ...
The contribution of cyclooxygenase-1 and -2 to persistent thromboxane biosynthesis in aspirin-treated essential thrombocythemia: Implications for antiplatelet therapy

Dragani A.; Pascale S.; Recchiuti A.; Mattoscio D.; Lattanzio S.; Petrucci G.; Mucci L.; Ferrante E.; Habib A.; Ranelletti F.O.; Ciabattoni G.; Davi G.; Patrono C.; Rocca B. (WASHINGTON1900 M STREET. NW SUITE 200, WASHINGTON, DC 20036 USA, 2010)

We tested whether cyclooxygenase 2 (COX-2) expression and unacetylated COX-1 in newly formed platelets might contribute to persistent thromboxane (TX) biosynthesis in aspirin-treated essential thrombocythemia (ET). Forty-one ...
A gain-of-function TBX20 mutation causes congenital atrial septal defects, patent foramen ovale and cardiac valve defects

Posch M.G.; Gramlich M.; Sunde M.; Schmitt K.R.; Lee S.H.Y.; Richter S.; Kersten A.; Perrot A.; Panek A.N.; Al Khatib I.H.; Nemer G.; Megarbane A.; Dietz R.; Stiller B.; Berger F.; Harvey R.P.; Ozcelik C. (LONDONBRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND, 2010)

Background: Ostium secundum atrial septal defects (ASDII) account for approximately 10percent of all congenital heart defects (CHD), and mutations in cardiac transcription factors, including TBX20, were identified as an ...
Tbx5 and the heart adaptation to life on earth [Tbx5 et l'adaptation du cœur à la vie sur terre]

Nemer G.; Nemer M. (LES ULIS CEDEX A17, AVE DU HOGGAR, PA COURTABOEUF, BP 112, F-91944 LES ULIS CEDEX A, FRANCE, 2010)

[No abstract available]
Impact of embryonic passaging of H9N2 virus on pathogenicity and stability of HA1- amino acid sequence cleavage site

Shaib H.A.; Cochet N.; Ribeiro T.; Abdel Nour A.M.; Nemer G.; Barbour E.K. (, 2010)

Background: Highly virulent Avian Influenza viruses might arise from avirulent strains following viral passaging. This work aims at studying the impact of embryonic passaging of H9N2 on the stability of the HA1 amino acid ...
Identification of new GATA4-small molecule inhibitors by structure-based virtual screening

El-Hachem N.; Nemer G. (OXFORDTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND, 2011)

Members of the GATA family of transcription factors are zinc finger proteins that were shown to play evolutionary conserved roles in cell differentiation and proliferation in different organisms. We hypothesized that by ...
Clinical Trials in the Middle East and North Africa

Serhal M. (Elsevier Inc.; SAN DIEGO525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA, 2011)

Clinical trials in the Middle East and North Africa are explained in this chapter. During this quest for new regions, the Middle East and North Africa (MENA) has been quietly developing a strong infrastructure, powered by ...

Now showing items 1-20 of 51

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Browsing Biochemistry and Molecular Genetics - Faculty Publications by Issue Date

Browsing Biochemistry and Molecular Genetics - Faculty Publications by Issue Date

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