AUB ScholarWorks

Browsing Biochemistry and Molecular Genetics by Issue Date

Browsing Biochemistry and Molecular Genetics by Issue Date

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  • Stem cells in neuroinjury and neurodegenerative disorders: Challenges and future neurotherapeutic prospects 
    Mouhieddine, Tarek H.; Kobeissy, Firas H.; Itani, Muhieddine M.; Nokkari, Amaly; Wang, Kevin Ka Wang (Editorial Board of Neural Regeneration Research, 2014)
    The prevalence of neurodegenerative diseases and neural injury disorders is increasing worldwide. Research is now focusing on improving current neurogenesis techniques including neural stem cell therapy and other biochemical ...
  • Passaging impact of H9N2 avian influenza virus in hamsters on its pathogenicity and genetic variability 
    Shaib, Houssam A.; Cochet, Nelly; Ribeiro, Thierry; Abdel Nour, Afif M.; Nemer, Georges M.; Azhar, Esam Ibraheem; Iyer, Archana P.; Kumosani, Taha Abdullah; Harakeh, Steve Mustapha; Barbour, Elie K. (Journal of Infection in Developing Countries, 2014)
    Introduction: Avian influenza viruses of the H9N2 subtype have been reported to cause human infections. This study demonstrates the impact of nasal viral passaging of avian H9N2 in hamsters on its cross species-pathogenic ...
  • Low-density lipoprotein levels and not mutation status predict Intima-media thickness in familial hypercholesterolemia 
    Fahed, Akl C.; Habib, Robert H.; Nemer, Georges M.; Azar, Sami T.; Andary, Rabih R.; Arabi, Mariam Toufic; Moubarak, Elie M.; Bitar, Fadi Fouad; Haddad, Fady F. (2014)
    Background Intima-media thickness (IMT) is a well-described marker of cardiovascular disease. In this study we aim to determine whether low-density lipoprotein (LDL) levels and disease-related mutation status can predict ...
  • Primary carnitine deficiency: Novel mutations and insights into the cardiac phenotype 
    Shibbani, Kamel; Fahed, Akl C.; Al-Shaar, Laila; Arabi, Mariam Toufic; Nemer, Georges M.; Bitar, Fadi Fouad; Majdalani, Marianne Nimah (2014)
    Solute carrier family 22 member 5 (SLC22A5) encodes a sodium-dependent ion transporter responsible for shuffling carnitine across the plasma membrane. This process provides energy for the heart, among other organs allowing ...
  • Antioxidant activity of pomegranate juice reduces acute lung injury secondary to hyperoxia in an animal model 
    Husari, Ahmad W.; Khayat, Aline; Bitar, Hala; Hashem, Yasmine; Rizkallah, Alain; Zaatari, Ghazi S.; El-Sabban, Marwan E. (BioMed Central Ltd., 2014)
    Background: Hyperoxia triggers the release of toxic reactive oxygen species (ROS). Pomegranate Juice (PJ) is a rich source of potent antioxidants. We assessed the effects of PJ supplementation on Acute Lung Injury (ALI) ...
  • Recent advances in application of biosensors in tissue engineering 
    Hasan, Anwarul Ul; Nurunnabi, Md; Morshed, Mahboob; Paul, Arghya; Polini, Alessandro; Kuila, Tapas; Al Hariri, Moustafa; Lee, Yong-kyu; Jaffa, Ayad A. (Hindawi Publishing Corporation, 2014)
    Biosensors research is a fast growing field in which tens of thousands of papers have been published over the years, and the industry is now worth billions of dollars. The biosensor products have found their applications ...
  • Recent updates on drug abuse analyzed by neuroproteomics studies: Cocaine, Methamphetamine and MDMA 
    Kobeissy, Firas H.; Mouhieddine, Tarek H.; Nokkari, Amaly; Itani, Muhieddine M.; Mouhieddine, Mohamed; Zhang, Zhiqun; Zhu, Rui; Gold, Mark S.; Wang, Kevin Ka Wang; Mechref, Yehia S. (Elsevier B.V., 2014)
    Currently, drug abuse and addiction represent a global public health concern with about 13.6 million people using illicit drugs in the USA alone. Substance abuse intervenes in normal brain functioning, causing alterations ...
  • Stability of urinary thromboxane A2 metabolites and adaptation of the extraction method to small urine volume 
    Pagliaccia, Francesca; Habib, Aida A.; Pitocco, Dario; Petrucci, Giovanna; Zaccardi, Francesco; Di Stasio, Enrico; Rocca, Bianca (2014)
    Background: Thromboxane (TX) A2 is a pro-thrombotic prostanoid synthesized by activated platelets, biotransformed into 11-dehydro-TXB 2, measurable in urines. Eleven-dehydro-TXB2 excretion is increased in high risk ...
  • CSF and Plasma Amyloid-β Temporal Profiles and Relationships with Neurological Status and Mortality after Severe Traumatic Brain Injury 
    Mondello, Stefania; Büki, Andràs; Barzó, Pál; Randall, Jeffrey D.; Provuncher, Gail K.; Hanlon, David W.; Wilson, David H.; Kobeissy, Firas H.; Jeromin, Andreas (Nature Publishing Group, 2014)
    The role of amyloid-β (Aβ) neuropathology and its significant changes in biofluids after traumatic brain injury (TBI) is still debated. We used ultrasensitive digital ELISA approach to assess amyloid-β1-42 (Aβ42) concentrations ...
  • Cell death mechanisms of plant-derived anticancer drugs: Beyond apoptosis 
    Gali-Muhtasib, Hala Uthman; Hmadi, Raed A.; Kareh, Mike; Tohme, Rita; Darwiche, Nadine D. (Springer New York LLC, 2015)
    Despite remarkable progress in the discovery and development of novel cancer therapeutics, cancer remains the second leading cause of death in the world. For many years, compounds derived from plants have been at the ...
  • Association between CLN3 (neuronal ceroid lipofuscinosis, CLN3 type) gene expression and clinical characteristics of breast cancer patients 
    Makoukji, Joelle; Raad, Mohamad A.; Genadry, Katia Christina; El-Sitt, Sally Boulos; Makhoul, Nadine J.; Saad Aldin, Ehab; Nohra, Eden A.; Jabbour, Mark N.; Sangaralingam, Ajanthah; Chelala, Claude; Habib, Robert H.; Boulos, Fouad I.; Tfayli, Arafat Hussein; Boustany, Rose Mary Naaman (Frontiers Media S.A., 2015)
    Breast cancer is the most common cancer in women worldwide. Elucidation of underlying biology and molecular pathways is necessary for improving therapeutic options and clinical outcomes. CLN3 protein (CLN3p), deficient in ...
  • Epidemiology and characteristics of urinary tract infections in children and adolescents 
    Hanna-Wakim, Rima H.; Ghanem, Soha T.; El Helou, Mona W.; Khafaja, Sarah A.; Shaker, Rouba A.; Hassan, Sara A.; Saad, Randa K.; Hedari, Carine P.; Khinkarly, Rima W.; Hajar, Farah M.; Bakhash, Marwan; El Karah, Dima; Akel, Imad S.; Rajab, Mariam El; Khoury, Mireille Lteif; Dbaibo, Ghassan S. (Frontiers Research Foundation, 2015)
    Background: Urinary tract infections (UTIs) are among the most common infections in the pediatric population. Over the last two decades, antibiotic resistance is increasing significantly as extended spectrum beta lactamase ...
  • NKX2-5 mutations in an inbred consanguineous population: Genetic and phenotypic diversity 
    Abou-Hassan, Ossama K.; Fahed, Akl C.; Batrawi, Manal; Arabi, Mariam Toufic; Refaat, Marwan M.; DePalma, Steven R.; Seidman, Jonathan G.; Seidman, Christine E.; Bitar, Fadi Fouad; Nemer, Georges M. (Nature Publishing Group, 2015)
    NKX2-5 mutations are associated with different forms of congenital heart disease. Despite the knowledge gained from molecular and animal studies, genotype-phenotype correlations in humans are limited by the lack of large ...
  • The Novel PKCθ from Benchtop to Clinic 
    Hage-Sleiman, Rouba; Hamze, Asmaa B.; Reslan, Lina; Kobeissy, Hadile; Dbaibo, Ghassan S. (Hindawi Limited, 2015)
    The protein kinases C (PKCs) are a family of serine/threonine kinases involved in regulating multiple essential cellular processes such as survival, proliferation, and differentiation. Of particular interest is the novel, ...
  • Leptin inhibits the Na+/K+ ATPase in Caco-2 cells via PKC and p38MAPK 
    El Zein, Ola; Usta, Julnar A.R.; El Moussawi, Layla; Kreydiyyeh, Sawsan Ibrahim (Elsevier Inc., 2015)
    We demonstrated previously an inhibitory effect of luminal leptin on glucose absorption in differentiated Caco-2 cells. Since this process is dependent on the Na+ gradient established by the Na+/K+ATPase this work was ...
  • Genetics of Sudden Cardiac Death 
    Refaat, Marwan M.; Hotait, Mostafa; London, Barry (Current Medicine Group LLC 1, 2015)
    Sudden cardiac death (SCD) is defined by the World Health Organization (WHO) as death within 1 h of symptom onset (witnessed) or within 24 h of being observed alive and symptom free (unwitnessed). It affects more than ...
  • The Mutation P.T613a in the Pore Helix of the Kv11.1 Potassium Channel is Associated with Long QT Syndrome 
    Poulsen, Kristian Lundgaard; Hotait, Mostafa; Calloe, Kirstine; Klaerke, Dan Arne; Rebeiz, Abdallah G.; Nemer, Georges M.; Tejada, Maria De Los Angeles; Refaat, Marwan M. (Blackwell Publishing Inc., 2015)
    Background Loss-of-function mutations in the voltage gated potassium channel Kv11.1 have been associated with the Long QT Syndrome (LQTS) type 2. We identified the p.T613A mutation in Kv11.1 in a family with LQTS. T613A ...
  • Proteomics studies in inner ear disorders: Pathophysiology and biomarkers 
    Alawieh, Ali Mostafa; Mondello, Stefania; Kobeissy, Firas H.; Shibbani, Kamel; Bassim, Marc Kaissar (Expert Reviews Ltd., 2015)
    Although proteomics has been exploited in a wide range of diseases for identification of biomarkers and pathophysiological mechanisms, there are still biomedical disciplines such as otology where proteomics platforms are ...
  • Molecular consequences of proprotein convertase 1/3 (PC1/3) inhibition in macrophages for application to cancer immunotherapy: A proteomic study 
    Duhamel, Marie; Rodet, Franck; Delhem, Nadira; Vanden-Abeele, Fabien; Kobeissy, Firas H.; Nataf, Serge; Pays, Laurent; Desjardins, Roxane; Gagnon, Hugo; Wisztorski, Maxence; Fournier, Isabelle; Day, Robert; SALZET, Michel (American Society for Biochemistry and Molecular Biology Inc., 2015)
    Macrophages provide the first line of host immune defense. Their activation triggers the secretion of pro-inflammatory cytokines and chemokines recruiting other immune cells. In cancer, macrophages present an M2 anti-inflammatory ...
  • Thiazole derivatives as inhibitors of cyclooxygenases in vitro and in vivo 
    El-Achkar, Ghewa A.; Jouni, Mariam; Mrad, May F.; Hirz, Taghreed; El Hachem, Nehme; Khalaf, Ali Ali; Hammoud, Soukaina; Fayyad-kazan, Hussein; Eid, Assaad A.; Badran, Bassam M.; Abou-Merhi, Raghida; Hachem, Ali; Hamade, Eva; Habib, Aida A. (Elsevier, 2015)
    Cyclooxygenases (COXs) are important membrane-bound heme containing enzymes important in platelet activation and inflammation. COX-1 is constitutively expressed in most cells whereas COX-2 is an inducible isoform highly ...

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