• Effects of subinhibitory concentrations of antimicrobial agents on escherichia coli O157:H7 Shiga toxin release and role of the SOS response 

  Nassar F.J.; Rahal E.A.; Sabra A.; Matar G.M. (NEW ROCHELLE140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA, 2013)

  Treatment of Escherichia coli O157:H7 by certain antimicrobial agents often exacerbates the patient's condition by increasing either the release of preformed Shiga toxins (Stx) upon cell lysis or their production through ...
• Streptococcus sp. and Staphylococcus aureus isolates from patients with psoriasis possess genes that code for toxins (superantigens): Clinical and therapeutic implications 

  El Ferezli J.; Jenbazian L.; Rubeiz N.; Kibbi A.-G.; Zaynoun S.; Abdelnoor A.M. (PHILADELPHIA325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA, 2008)

  Superantigens are powerful T lymphocyte-stimulating agents that are believed to contribute to the pathogenesis of certain diseases such as psoriasis. Toxins produced by Streptococcus pyogenes and Staphylococcus aureus are ...
• Oxacillinase-mediated resistance to carbapenems in Klebsiella pneumoniae from Lebanon 

  Matar G.M.; Cuzon G.; Araj G.F.; Naas T.; Corkill J.; Kattar M.M.; Nordmann P. (MALDENCOMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA, 2008)

  [No abstract available]
• HLA allele associations and V-beta T-lymphocyte expansions in patients with psoriasis, harboring toxin-producing Staphylococcus aureus 

  Ajib R.; Janbazian L.; Rahal E.; Matar G.M.; Zaynoun S.; Kibbi A.-G.; Abdelnoor A.M. (NEW YORK410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA, 2005)

  HLA alleles have been associated with psoriasis. Toxin-producing strains of Staphylococcus aureus behave as superantigens, and if present in patients, might play a role in the exacerbation of psoriatic lesions by activating ...
• Antibacterial agents and innate immunity 

  Abdelnoor A.M. (, 2013)

  On their own, antibacterial agents cannot cure an infectious disease. They need help from the innate immune response followed by the adaptive immune response and inflammatory response. An overview of Toll-Like Receptors ...
• Patented small molecules against psoriasis 

  Abdelnoor A.M. (LONDONTELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND, 2009)

  Background: It is hypothesized that psoriasis is an autoimmune disease. The most recent therapeutic approach that proved to be more effective than earlier methods of treatment is the use of mAb-fusion proteins. Efforts ...
• Diffusion-weighted whole-body imaging with background body signal suppression in Castleman disease 

  Khalil G.; Gaspard D.; Jreige M.; Nawfal G. (, 2013)

  Castleman's disease (CD) is a rare lymphoproliferative disease characterized by angiofollicular lymph node hyperplasia. The case of a 74-year-old man with multicentric CD of the plasma cell type is described. The imaging ...
• Preparation of anti-Aspergillus fumigatus antibodies in egg laying hens and their protective efficacy in BALB-c mice 

  Chakhtoura M.; Rahal E.; Halas Y.; Al-Sabbagh Z.; Abdelnoor A.M. (, 2008)

  The aim of this study was to prepare anti-Aspergillus fumigatus antibodies in egg-laying hens and test their protective efficacy in BALB-c mice. Heat-killed A fumigatus was emulsified with Freunds complete and incomplete ...
• Review study on external-hospital bacteria as a source of infection and antimicrobial resistance in Lebanon 

  Abdelnoor A.M.; Chokr S.; Fayad L.; Al-Akl N. (, 2013)

  Most studies done on bacteria in Lebanon are on hospital isolates. However, some of the sources of hospital isolates might be from contaminated foods and water that are imported into hospitals. Studies done in the Department ...
• Preparation of anti-Candida albicans antibodies in an egg-laying hen and their protective efficacy in mice 

  Abdelnoor A.M.; Rahal E.; Zeidan J.A.; Halas Y.A.; Sleiman F. (, 2006)

  Limited antifungal drugs, their high toxicity, and the emergence of resistant Candida albicans strains indicate the need for novel therapeutic strategies. The objectives of this study were to prepare antibodies against C ...
• The effects of Alcea rosea L., Malva sylvestris L. and Salvia libanotica L. water extracts on the production of anti-egg albumin antibodies, interleukin-4, gamma interferon and interleukin-12 in BALB-c mice 

  El Ghaoui W.B.J.; Ghanem E.B.; Chedid L.A.; Abdelnoor A.M. (CHICHESTERTHE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND, 2008)

  Polysaccharides obtained from certain plants have been reported to have immunomodulatory properties. As a consequence of these reports the aim of this study was to investigate some immunomodulatory properties of water ...
• Effects of catalase and 1400W on the number of interleukin-4 and interferon-γ secreting spleen cells in mice injected with ovalbumin and alum 

  Al-Akl N.S.; Ismail M.; Khaliefeh F.; Usta J.; Abdelnoor A.M. (LONDONTELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND, 2012)

  Context: Alum is thought to induce inflammation resulting in the release of danger signals such as uric acid (UA) which in turn enhances the immune response to an antigen. Hydrogen peroxide (H2O2) is produced as a byproduct ...
• Prevalence of the genes encoding extended-spectrum β-lactamases, in Escherichia coli resistant to β-lactam and non-β-lactam antibiotics 

  Matar G.M.; Al Khodor S.; El-Zaatari M.; Uwaydah M. (LEEDSHUDSON RD, LEEDS LS9 7DL, ENGLAND, 2005)

  The prevalences of extended-spectrum β-lactamases (ESBL) and their encoding bla genes, TEM, SHV and CTX_M, were investigated in isolates of Escherichia coli that were resistant to β-lactam and-or non-β-lactam antibiotics. ...
• Decrease in Shiga toxin expression using a minimal inhibitory concentration of rifampicin followed by bactericidal gentamicin treatment enhances survival of Escherichia coli O157:H7-infected BALB-c mice 

  Rahal E.A.; Kazzi N.; Sabra A.; Abdelnoor A.M.; Matar G.M. (LONDON236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND, 2011)

  Background: Treatment of Escherichia coli O157:H7 infections with antimicrobial agents is controversial due to an association with potentially fatal sequelae. The production of Shiga toxins is believed to be central to the ...
• Identification and antibacterial resistance of bacteria isolated from poultry 

  El-Rami F.E.; Sleiman F.T.; Abdelnoor A.M. (WARSAWCHELMSKA STR 30-34, WARSAW, 00-725, POLAND, 2012)

  Food-borne infections are among the prominent health hazards. Antibacterial agents (ABA) are usually administered to poultry in Lebanon as antibiotic growth promoters (AGP), which might lead to the dissemination of resistant ...
• Escherichia coli O157:H7-Clinical aspects and novel treatment approaches. 

  Rahal E.A.; Kazzi N.; Nassar F.J.; Matar G.M. (LAUSANNEPO BOX 110, LAUSANNE, 1015, SWITZERLAND, 2012)

  Escherichia coli O157:H7 is a notorious pathogen often contracted by intake of contaminated water or food. Infection with this agent is associated with a broad spectrum of illness ranging from mild diarrhea and hemorrhagic ...
• The effect of five antibacterial agents on the physiological levels of serum nitric oxide in mice 

  Barsoumian H.; El-Rami F.; Abdelnoor A.M. (LONDONTELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND, 2011)

  In addition to their action on microorganisms, antibacterial agents have been reported to affect host defense mechanisms. Nitric oxide (NO) that is produced by a number of cell types in the innate immune response is ...
• Monoclonal antibodies used as prophylactic, therapeutic and diagnostic agents 

  Chakhtoura M.; Abdelnoor A.M. (LONDONTELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND, 2010)

  Monoclonal antibodies can be of mouse, part mouse part human (chimeric, humanized), or of human origin. Their preparation involves hybridoma, gene cloning, gene recombination, phage display, and gene transfection techniques. ...
• ATM regulates Mre11-dependent DNA end-degradation and microhomology- mediated end joining 

  Rahal E.A.; Henricksen L.A.; Li Y.; Williams R.S.; Tainer J.A.; Dixon K. (, 2010)

  The human disorder ataxia telangiectasia (AT), which is characterized by genetic instability and neurodegeneration, results from mutation of the ataxia telangiectasia mutated (ATM) kinase. The loss of ATM leads to cell ...
• Role of rifampicin in limiting Escherichia coli O157:H7 Shiga-like toxin expression and enhancement of survival of infected BALB-c mice 

  Rahal E.A.; Kazzi N.; Kanbar A.; Abdelnoor A.M.; Matar G.M. (AMSTERDAMPO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS, 2011)

  The sequelae of infection with Escherichia coli O157:H7 include the potentially fatal haemolytic uraemic syndrome. The pathobiological process of E. coli O157:H7 is chiefly dependent on the production of Shiga-like toxins ...

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