AUB ScholarWorks

Browsing Experimental Pathology, Microbiology, and Immunology by Issue Date

Browsing Experimental Pathology, Microbiology, and Immunology by Issue Date

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  • The Mediterranean Region: A Reservoir for CTX-M-ESBLProducing Enterobacteriacae 
    Cheaito, Katia A.; Matar, Ghassan (Hashemite University, 2014)
    The incidence of ESBL-producing bacteria is increasing worldwide, which represents a challenge for the healthcare systems. More recently, the emergence of the CTX-M group has been frequently reported as being associated ...
  • Characterization of human influenza viruses in lebanon during 2010-2011 and 2011-2012 post-pandemic seasons 
    Zaraket, Hassan; Dapat, Clyde P.; Ghanem, Soha T.; Ali, Zainab; Lteif, Mireille; Kondo, Hiroshi; Dapat, Isolde Caperig; Saito, Kousuke; Kayali, Ghazi; Suzuki, Hiroshi; Dbaibo, Ghassan S.; Saito, Reiko (S. Karger AG, 2014)
    Objective: To genetically characterize human influenza viruses and their susceptibilities to antivirals during two post-pandemic seasons in Lebanon.; Methods: Influenza virus was isolated from nasopharyngeal swabs that ...
  • Characterization of an H4N2 influenza virus from Quails with a multibasic motif in the hemagglutinin cleavage site 
    Wong, Sooksan; Yoon, Sun-woo; Zanin, Mark P.; Song, Min-suk; Oshansky, Christine M.; Zaraket, Hassan; Sonnberg, Stephanie; Rubrum, Adam M.; Seiler, Patrick J.; Ferguson, Angela Damon; Krauss, Scott L.; Cardona, Carol J.; Webby, Richard John; Crossley, Beate M. (Academic Press Inc., 2014)
    The cleavage motif in the hemagglutinin (HA) protein of highly pathogenic H5 and H7 subtypes of avian influenza viruses is characterized by a peptide insertion or a multibasic cleavage site (MBCS). Here, we isolated an ...
  • Prevalence of clostridium difficile toxinotypes in infected patients at a tertiary care center in lebanon 
    Moukhaiber, Romy; Araj, George F.; Kissoyan, Kohar Annie B.; Cheaito, Katia A.; Matar, Ghassan (Journal of Infection in Developing Countries, 2015)
    Introduction: Due to the increase in the incidence of Clostridium difficile associated diseases at a tertiary care center in Lebanon, this study was undertaken to determine the prevalent C. difficile toxinotypes. Methodology: ...
  • A transgenic Drosophila melanogaster model to study human T-lymphotropic virus oncoprotein Tax-1-driven transformation in vivo 
    Shirinian, Margret; Kambris, Zakaria; Hamadeh, Lama N.; Grabbe, Caroline; Journo, Chloé; Mahieux, Renaud; Bazarbachi, Ali Abdul Hamid (American Society for Microbiology, 2015)
    Human T-cell lymphotropic virus type 1 (HTLV-1)-induced adult T-cell leukemia/lymphoma is an aggressive malignancy. HTLV-2 is genetically related to HTLV-1 but does not cause any malignant disease. HTLV-1 Tax transactivator ...
  • Epidemiology, clinical manifestations, and molecular typing of salmonella typhi isolated from patients with typhoid fever in Lebanon 
    Kanj, Souha S.; Kanafani, Zeina A.; Shehab, Marwa; Sidani, Nisreen; Baban, Tania A.; Baltajian, Kedak; Dakdouki, Ghenwa K.; Zaatari, Mohamad; Araj, George F.; Hanna-Wakim, Rima H.; Dbaibo, Ghassan S.; Matar, Ghassan (Elsevier Ltd, 2015)
    The objective of this study was to examine the epidemiology and the clinical manifestations of typhoid fever as well as the susceptibility and strain relatedness of Salmonella typhi isolates in Lebanon from 2006 to 2007. ...
  • Epstein-barr virus and human herpes virus 6 type A DNA enhance IL-17 production in mice 
    Rahal, Elias A.; Hajjar, Helene; Rajeh, Mirna; Yamout, Bassem I.; Abdelnoor, Alexander Michael (Mary Ann Liebert Inc., 2015)
    Several studies have shown a potential association between the Herpesviridae members, the Epstein-Barr virus (EBV) and Human herpes virus 6 (HHV-6), and an increased risk of autoimmune disease development. Because of the ...
  • Influenza and its treatment during pregnancy: A review 
    Ghulmiyyah, Labib M.; Alame, Malak M.; Mirza, Fadi Ghazi; Zaraket, Hassan; Nassar, Anwar H. (IOS Press, 2015)
    The influenza viral infection has dramatic effects during pregnancy on the mother and the fetus. We present a review article on the prevention and treatment recommendations of influenza infection in pregnant women, and the ...
  • Escherichia coli isolated from urinary tract infections of Lebanese patients between 2005 and 2012: Epidemiology and profiles of resistance 
    Daoud, Ziad D.; Salem-Sokhn, Elie; Masri, Khalil; Cheaito, Katia A.; Haidar-Ahmad, Nathaline; Matar, Ghassan; Doron, Shira Idit (Frontiers Media S.A., 2015)
    The early treatment of urinary tract infections (UTIs) is directly related to decrease in morbidity, which makes the empirical treatment of great importance. Recently, beta lactamases of several types have emerged as ...
  • Retinoic acid and arsenic trioxide trigger degradation of mutated NPM1, resulting in apoptosis of AML cells 
    El-Hajj, Hiba Ahmad; Dassouki, Zeina; Berthier, Caroline P.; Raffoux, Emmanuel; Adès, Lionel; Legrand, Ollivier; Hleihel, Rita S.; Sahin, Umut; Tawil, Nadim M.; Salameh, Ala; Zibara, Kazem; Darwiche, Nadine D.; Mohty, Mohamad; Dombret, Hervè; Fénaux, Pierre; de Thȩ, Hugues B.; Bazarbachi, Ali Abdul Hamid (American Society of Hematology, 2015)
    Nucleophosmin-1 (NPM1) is the most frequently mutated gene in acute myeloid leukemia (AML). Addition of retinoic acid (RA) to chemotherapy was proposed to improve survival of some of these patients. Here, we found that RA ...
  • Non-random aneuploidy specifies subgroups of pilocytic astrocytoma and correlates with older age 
    Fontebasso, Adam M.; Shirinian, Margret; Khuong-Quang, Dong Anh; Bechet, Denise; Gayden, Tenzin; Kool, Marcel; de Jay, Nicolas; Jacob, Karine; Gerges, Noha; Hutter, Barbara; Şeker-Cin, Huriye; Witt, Hendrik; Montpetit, Alexandre; Brunet, Sébastien; Lepage, Pierre; Bourret, Geneviève; Klekner, Álmos P.; Bognár, László; Hauser, Péter; Garami, Miklós; Farmer, Jean Pierre; Montes, José Luis Temes; Atkinson, Jeffrey D.; Lambert, Sally R.; Kwan, Tony; Korshunov, Andrey G.; Tabori, Uri; Peter Collins, V.; Albrecht, Steffen; Faury, Damien; Pfister, Stefan M.; Paulus, Werner; Hasselblatt, Martin; Jones, David T.W.; Jabado, Nada (Impact Journals LLC, 2015)
    Pilocytic astrocytoma (PA) is the most common brain tumor in children but is rare in adults, and hence poorly studied in this age group. We investigated 222 PA and report increased aneuploidy in older patients. Aneuploid ...
  • Phospho-MEK1/2 and uPAR expression determine sensitivity of AML blasts to a urokinase-activated anthrax lethal toxin (PrAgU2/LF) 
    Bekdash, Amira; Darwish, Manal; Timsah, Zahra; Kassab, Elias; Ghanem, Hadi; Najjar, Vicky F.; Ghosn, Marwan G.; Nasser, Selim M.; El-Hajj, Hiba Ahmad; Bazerbachi, Ali; Liu, Shihui; Leppla, Stephen Howard; Frankel, Arthur Edward; Abi-Habib, Ralph J. (Translational Oncology Editorial Office, 2015)
    In this study, we attempt to target both the urokinase plasminogen activator and the mitogen-activated protein kinase pathway in acute myeloid leukemia (AML) cell lines and primaryAMLblasts using PrAgU2/LF, a urokinase-activated ...
  • Effect of rifampicin and gentamicin on shiga toxin 2 expression level and the SOS response in Escherichia coli O104:H4 
    Fadlallah, Sukayna M.; Rahal, Elias A.; Sabra, Ahmad H.; Kissoyan, Kohar Annie B.; Matar, Ghassan (Mary Ann Liebert Inc., 2015)
    Background: A novel pathotype, Shiga toxin-producing Escherichia coli O104:H4, was the cause of a severe outbreak that affected European countries, mainly Germany, in 2011. The effect of different regimens of rifampicin ...
  • Mammalian adaptation of influenza A(H7N9) virus is limited by a narrow genetic bottleneck 
    Zaraket, Hassan; Baranovich, Tatiana; Kaplan, Bryan S.; Carter, Robert A.; Song, Min-suk; Paulson, James C.; Rehg, Jerold E.; Bahl, Justin; Crumpton, Jeri Carol; Seiler, Jon Patrick; Edmonson, Michael N.; Wu, Gang; Karlsson, Erik A.; Fabrizio, Thomas P.; Zhu, Huachen Maria; Guan, Yi; Husain, Matloob; Schultz-Cherry, Stacey L.; Krauss, Scott L.; McBride, Ryan; Webster, Robert G.; Govorkova, Elena A.; Zhang, Jinghui; Russell, Charles J.; Webby, Richard John (Nature Publishing Group, 2015)
    Human infection with avian influenza A(H7N9) virus is associated mainly with the exposure to infected poultry. The factors that allow interspecies transmission but limit human-to-human transmission are unknown. Here we ...
  • Atorvastatin reduces the survival of Candida albicans-infected BALB/c mice 
    Rahal, Elias A.; Constantin, Wissam N.; Zeidan, Nabil; Abdelnoor, Alexander Michael (Frontiers Media S.A., 2015)
    Several antimicrobial and immunosuppressive effects have been attributed to the statins class of antihyperlipidemia drugs. Several studies have also indicated clinical benefits for the use of statins during the management ...
  • Assessment of combination therapy in BALB/c mice injected with carbapenem-resistant Enterobacteriaceae strains 
    Salloum, Noor A.; Kissoyan, Kohar Annie B.; Fadlallah, Sukayna M.; Cheaito, Katia A.; Araj, George F.; Hanna-Wakim, Rima H.; Kanj, Souha S.; Kanafani, Zeina A.; Dbaibo, Ghassan S.; Matar, Ghassan (Frontiers Media S.A., 2015)
    Monotherapeutic options for carbapenem resistant infections are limited. Studies suggest that combination therapy may be associated with better outcomes than monotherapies. However, this is still controversial. This study ...
  • Draft genome sequence of Klebsiella pneumoniae KGM-IMP216 harboring blaCTX-M-15, blaDHA-1, blaTEM-1B, blaNDM-1, blaSHV-28, and blaOXA-1, isolated from a patient in Lebanon 
    Tokajian, Sima T.; Eisen, Jonathan A.; Jospin, Guillaume; Matar, Ghassan; Araj, George F.; Coil, David A. (American Society for Microbiology, 2016)
    We present the draft genome of highly drug-resistant Klebsiella pneumoniae KGM-IMP216, isolated from a urine sample collected from a patient in Lebanon. The draft genome sequence consisted of 77 contigs, including a combined ...
  • ATL-derived exosomes modulate mesenchymal stem cells: Potential role in leukemia progression 
    El-Saghir, Jamal A.; Nassar, Farah J.; Tawil, Nadim M.; El-Sabban, Marwan E. (BioMed Central Ltd., 2016)
    Background: Exosomes are membrane nano-vesicles secreted by a multitude of cells that harbor biological constituents such as proteins, lipids, mRNA and microRNA. Exosomes can potentially transfer their cargo to other cells, ...
  • Characterization of influenza outbreaks in Lebanon during the 2013/14 and 2014/15 seasons 
    Saito, Reiko; Akinobu, H.; Shaker, Rouba A.; Akel, Imad S.; Assaf-Casals, Aia; Lteif, Mireille; Odagiri, Takashi; Inaba, R.; Soudani, Nadia Y.; Khafaja, Sarah A.; Ghanem, Soha T.; Rajab, Mariam El; Shobugawa, Yugo; Dbaibo, Ghassan S.; Zaraket, Hassan (World Health Organization, 2016)
    Despite the significant burden of influenza outbreaks, active disease monitoring has been largely absent in the Middle East, including Lebanon. In this study we characterized influenza virus in 440 nasopharyngeal swabs ...
  • Genotypic and virulence characteristics of listeria monocytogenes recovered from food items in Lebanon 
    Haidar-Ahmad, Nathaline; Kissoyan, Kohar Annie B.; Fadlallah, Sukayna M.; el-Hajj, Rima; Saleh, Majd; Ghosn, Nada; Matar, Ghassan (Journal of Infection in Developing Countries, 2016)
    Introduction: Listeria monocytogenes is the agent of listeriosis, a life threatening foodborne disease for immunocompromised patients and pregnant women. This bacterium is not routinely screened for in Lebanon and there ...

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