Browsing Department of Biology by Issue Date

Now showing items 1-20 of 302

Wild almonds gone wild: revisiting Darwin’s statement on the origin of peaches

Yazbek, Mariana M.; Al-Zein, Mohammad Souheil (Kluwer Academic Publishers, 2014)

There is a general consensus that cultivated almond was domesticated in western Asia while cultivated peach was domesticated in China; however, the lack of a comprehensive phylogeny of cultivated peaches and almonds and ...
Koch's postulate in reproduction of broiler coccidiosis by co-infection with eight most common Eimeria spp.: A model for future evaluation of new biologics

Barbour, Elie K.; Ayyash, Danielle B.; Shaib, Houssam A.; Bragg, Robert Richard; Azhar, Esam Ibraheem; Iyer, Archana P.; Harakeh, Steve Mustapha; Kambris, Zakaria; Kumosani, Taha Abdullah (Veterinary Solutions LLC, 2014)

The purpose of this research is to establish a model of Koch's postulate for reproducing coccidiosis in broilers by co-infection with eight most common Eimeria spp. involved in this economic disease, in an attempt to use ...
The proto-oncoprotein c-Cbl protects cells against oxidative stress by down- regulating apoptosis and is highly expressed in several cancers

Yakoub, Sadok; El-Chami, Nisrine; Kaszás, Krisztián; Malek, Mouhannad; El Sirkasi, Mohamed; Smith, Colin Andrew; Baydoun, Elias Abdel Hasan; Tabone, Éric; Manie ́, Serge N.; Daniel Régnier, C. L. (OMICS Publishing Group, 2014)

Objective: To determine the role of c-Cbl in the apoptotic process, using several means, stressing the role of oxidative stress in cancer cells. Methods: Prostatic epithelial cell apopotosis of c-Cbl-/-mice were compared ...
Epigallocatechin-3-gallate inhibits tax-dependent activation of nuclear factor Kappa B and of matrix metalloproteinase 9 in human T-cell lymphotropic virus-1 positive leukemia cells

Harakeh, Steve Mustapha; Diab-Assaf, Mona; Azar, Rania; Hassan, Hani Mutlak A.; Tayeb, Safwan; Abou-El-Ardat, Khalil; Damanhouri, Ghazi Abdullah; Qadri, Mohammad Ishtiaq; Abuzenadah, Adel Mohammad; Chaudhary, Adeel Gulzar Ahmed; Kumosani, Taha Abdullah; Niedzwiecki, Aleksandra; Rath, Matthias; Yacoub, Haitham Ahmed; Azhar, Esam Ibraheem; Barbour, Elie K. (Asian Pacific Organization for Cancer Prevention, 2014)

Epigallocatechin-3-gallate (EGCG) is the most abundant polyphenol molecule from green tea and is known to exhibit antioxidative as well as tumor suppressing activity. In order to examine EGCG tumor invasion and suppressing ...
A serine protease homolog negatively regulates TEP1 consumption in systemic infections of the malaria vector Anopheles gambiae

Yassine, Hassan; Kamareddine, Layla; Chamat, Soulaïma S.; Christophides, George K.; Osta, Mike A. (S. Karger AG, 2014)

Clip domain serine protease homologs are widely distributed in insect genomes and play important roles in regulating insect immune responses, yet their exact functions remain poorly understood. Here, we show that CLIPA2, ...
Microbial transformation of nandrolone with Cunninghamella echinulata and Cunninghamella blakesleeana and evaluation of leishmaniacidal activity of transformed products

Baydoun, Elias Abdel Hasan; Karam, Martin M.; Atia-tul-Wahab,; Khan, Mahwish Shafi Ahmed; Ahmad, Malik Shoaib; Samreen,; Smith, Colin Andrew; Abdel-Massih, Roula; Choudhary, Mohammed Iqbal (Elsevier Inc., 2014)

Therapeutic potential of nandrolone and its derivatives against leishmaniasis has been studied. A number of derivatives of nandrolone (1) were synthesized through biotransformation. Microbial transformation of nandrolone ...
Ceramide and its metabolites modulate time-dependently the activity of the Na+/K+ ATPase in HepG2 cells

Kreydiyyeh, Sawsan Ibrahim; Dakroub, Zeina (Elsevier Ltd, 2014)

Ceramide is involved in the regulation of many cellular processes including cell proliferation and apoptosis, which are accompanied respectively with a decrease and an increase in the activity of the Na+/K+ ATPase. These ...
Spontaneous release of Epiretinal membrane in a young weight-lifting athlete by presumed central rupture and centrifugal pull

Mansour, Ahmad Mohammed Farid Mahmoud; Mansour, Hana A.; Arévalo, José Fernando (Dove Medical Press Ltd, 2014)

This patient presented for surgery at the age of 32 years, 14 months after his initial complaint of metamorphopsia and visual loss in the right eye. Past tests demonstrated a whitish epiretinal membrane (ERM) with translucent ...
A lag of 25 years: Evidence from an old capture of Fistularia commersonii Rüppell, 1838 from Lebanon (Mediterranean Sea)

Bariche, Michel; Kazanjian, G.; Azzurro, Ernesto (Blackwell Publishing Ltd, 2014)
MiRNA as potential biomarkers of breast cancer in the lebanese population and in young women: A pilot study

Nassar, Farah J.; Sabban, Maya El; Khoueiry-Zgheib, Nathalie; Tfayli, Arafat Hussein; Boulos, Fouad I.; Jabbour, Mark N.; El-Saghir, Nagi S.; Talhouk, Rabih S.; Bazarbachi, Ali Abdul Hamid; Calin, George Adrian; Nasr, Rihab R. (Public Library of Science, 2014)

Relative to western populations, the percentage of women diagnosed with breast cancer at a young age in Lebanon is high. While the younger age of the Lebanese population compared to the West certainly contributes to this ...
Thymoquinone-induced conformational changes of PAK1 interrupt prosurvival MEK-ERK signaling in colorectal cancer

el-Baba, Chirine Omar; Mahadevan, Vijayalakshmi; Fahlbusch, Fabian Benedikt; Suma Mohan, S.; Rau, Tilmann T.; Gali-Muhtasib, Hala Uthman; Schneider-Stock, Regine (BioMed Central Ltd., 2014)

Background: Thymoquinone (TQ) was shown to reduce tumor growth in several cancer models both in vitro and in vivo. So far only a few targets of TQ, including protein kinases have been identified. Considering that kinases ...
Fungal transformation and T-cell proliferation inhibitory activity of melengestrol acetate and its metabolite

Baydoun, Elias Abdel Hasan; Bano, Saira; Atia-tul-Wahab,; Jabeen, Almas; Yousuf, Sammer; Mesaik, M. Ahmed; Smith, Colin Andrew; Choudhary, Mohammed Iqbal (Elsevier Inc., 2014)

Biotransformation of melengestrol acetate (MGA, 17α-acetoxy-6-methyl- 16-methylenepregna-4,6-diene-3,20-dione) (1) was investigated for the first time by using fungal cultures. Incubation of compound 1 with Cunninghamella ...
Copper chelation selectively kills colon cancer cells through redox cycling and generation of reactive oxygen species

Fatfat, Maamoun; Abou-Merhi, Raghida; Rahal, Omar Nasser; Stoyanovsky, Detcho A.; Zaki, Angela M.; Haidar, Hazar; Kagan, Valerian E.; Gali-Muhtasib, Hala Uthman; Machaca, Khaled (BioMed Central Ltd., 2014)

Background: Metals including iron, copper and zinc are essential for physiological processes yet can be toxic at high concentrations. However the role of these metals in the progression of cancer is not well defined. Here ...
Spatial heterogeneity in the mediterranean biodiversity hotspot affects barcoding accuracy of its freshwater fishes

Geiger, Matthias Felix; Herder, Fabian; Monaghan, Michael T.; Almada, Vítor Carvalho; Barbieri, Roberta; Bariche, Michel; Berrebi, Patrick; Bohlen, Jörg; Casal-López, Miriam; Delmastro, Giovanni Battista; Denys, Gaël P.J.; Dettaï, Agnès; Doadrio, Ignácio; Kalogianni, Eleni; Kärst, Heiko; Kottelat, Maurice; Kovačić, Marcelo; Laporte, Martin; Lorenzoni, Massimo; Marčić, Zoran; Özuluğ, Müfit; Perdices, Anabel; Perea, Silvia; Persat, Henri; Porcelotti, S.; Puzzi, Cesare Mario; Robalo, Joana Isabel; Šanda, Radek; Schneider, M.; Šlechtová, Vendula Bohlen; Stoumboudi, Maria Th; Walter, S.; Freyhof, Jörg (2014)

Incomplete knowledge of biodiversity remains a stumbling block for conservation planning and even occurs within globally important Biodiversity Hotspots (BH). Although technical advances have boosted the power of molecular ...
Effect of Dietary Protein Level on Growth Performance and Blood Parameters of Marbled Spinefoot Siganus rivulatus

Abou-Daoud, Y.; Ghanawi, Joly; Farran, Mohammad Talal; Davis, Donald Allen; Saoud, Imad Patrick (Taylor and Francis Inc., 2014)

The present study evaluated the effect of dietary protein levels on growth performance and blood parameters of juvenile marbled spinefoot (Siganus rivulatus). Five semipurified, isoenergetic (14.2 MJ digestible energy/kg; ...
Comparative Antiproliferative activities of wood and seeds essential oils of Juniperus Oxycedrus L. against K562 human chronic myelogenous leukemia cells

Saab, Antoine Michael; Gali-Muhtasib, Hala Uthman; Maietti, Silvia; Grandini, Alessandro; Rossi, Damiano; Lampronti, Ilaria; Gallerani, Eleonora; Fabbri, Enrica; Gambari, Roberto (Taylor and Francis Inc., 2014)

The species Juniperus oxycedrus L. is a member of Cupressaceae family. The chemical composition and antiproliferative activity of wood and seeds essential oils of J. oxycedrus, grown wild in Lebanon, were evaluated in order ...
First record of the blacktip grouper Epinephelus fasciatus (Teleostei: Serranidae) in the Mediterranean Sea

Bariche, Michel; Heemstra, Phillip C. (Cambridge University Press, 2014)

A specimen of the Indo-Pacific blacktip grouper was collected at a depth of 20 m from off the coast of Lebanon. This constitutes the first record of the species in the Mediterranean and adds to the number of exotic serranids ...
The quinoxaline di-N-oxide DCQ blocks breast cancer metastasis in vitro and in vivo by targeting the hypoxia inducible factor-1 pathway

Ghattass, Khaled Imad; El-Sitt, Sally Boulos; Zibara, Kazem; Rayes, Saide; Haddadin, Makhluf J.; El-Sabban, Marwan E.; Gali-Muhtasib, Hala Uthman (2014)

Background: Although tumor hypoxia poses challenges against conventional cancer treatments, it provides a therapeutic target for hypoxia-activated drugs. Here, we studied the effect of the hypoxia-activated synthetic ...
Thymoquinone: Fifty years of success in the battle against cancer models

Schneider-Stock, Regine; Fakhoury, I. H.; Zaki, Angela M.; el-Baba, Chirine Omar; Gali-Muhtasib, Hala Uthman (2014)

Thymoquinone (TQ), the main active constituent of black seed essential oil, exhibits promising effects against inflammatory diseases and cancer. TQ, modulates signaling pathways that are key to cancer progression, and ...
A transgenic Drosophila melanogaster model to study human T-lymphotropic virus oncoprotein Tax-1-driven transformation in vivo

Shirinian, Margret; Kambris, Zakaria; Hamadeh, Lama N.; Grabbe, Caroline; Journo, Chloé; Mahieux, Renaud; Bazarbachi, Ali Abdul Hamid (American Society for Microbiology, 2015)

Human T-cell lymphotropic virus type 1 (HTLV-1)-induced adult T-cell leukemia/lymphoma is an aggressive malignancy. HTLV-2 is genetically related to HTLV-1 but does not cause any malignant disease. HTLV-1 Tax transactivator ...

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Browsing Department of Biology by Issue Date

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