Browsing Department of Biology by Title

Now showing items 1-20 of 302

2-Nucleobase-substituted 4,6-Diaminotriazine Analogs: Synthesis and Anti-cancer Activity in 5-Fluorouracil-sensitive and Resistant Colorectal Cancer Cells

Hamze, Khalil; Abdallah, Rola H.; Younis, Nour K.; Fardoun, Manal Muin; Darwiche, Nadine D.; Kobeissy, Firas H.; Iratni, Rabah; Bouhadir, Kamal Hani; Eid, Ali H. (Bentham Science Publishers, 2023)

Background: Cancer continues to be the second leading cause of death worldwide, with colorectal cancer (CRC) being the third most common type. Despite significant advances in cancer therapies, the current treatment of CRC ...
7-O-methylpunctatin, a novel homoisoflavonoid, inhibits phenotypic switch of human arteriolar smooth muscle cells

Fardoun, Manal Muin; Iratni, Rabah; Dehaini, Hassan; Eid, Assaad A.; Ghaddar, Tarek H.; El-Elimat, Tamam M.; Alali, Feras Qasem; Badran, Adnan; Eid, Ali H.; Baydoun, Elias Abdel Hasan (MDPI AG, 2019)

Remodeling of arterioles is a pivotal event in the manifestation of many inflammation-based cardio-vasculopathologies, such as hypertension. During these remodeling events, vascular smooth muscle cells (VSMCs) switch from ...
A Case Report of a Lebanon Viper (Montivipera bornmuelleri) Envenomation in a Child

Tabbara, Faysal; Abdul-Nabi, Sarah S.; Sadek, Riyad A.; Kazzi, Ziad N.; El Zahran, Tharwat (University of California - Department of Emergency Medicine, 2022)

Introduction: Snake envenomation is a serious public health concern. In the Middle East little is known about snakebite envenomation, which raises several challenges for emergency physicians caring for these patients. Case ...
A comparative analysis of L1 retrotransposition activities in human genomes suggests an ongoing increase in L1 number despite an evolutionary trend towards lower activity

Wehbi, Sawsan Sami; Zu Dohna, Heinrich (BioMed Central Ltd, 2021)

Background: LINE-1 (Long Interspersed Nuclear Elements, L1) retrotransposons are the only autonomously active transposable elements in the human genome. The evolution of L1 retrotransposition rates and its implications for ...
A comparative analysis of Wolbachia-induced host reproductive phenotypes reveals transition rate heterogeneity

Zu Dohna, Heinrich; Houry, Carine; Kambris, Zakaria (John Wiley and Sons Ltd, 2018)

The endosymbiotic bacterium Wolbachia infects a wide range of arthropods and their relatives. It is an intracellular parasite transmitted through the egg from mother to offspring. Wolbachia can spread and persist through ...
A lag of 25 years: Evidence from an old capture of Fistularia commersonii Rüppell, 1838 from Lebanon (Mediterranean Sea)

Bariche, Michel; Kazanjian, G.; Azzurro, Ernesto (Blackwell Publishing Ltd, 2014)
A Novel Antidipteran Bacillus thuringiensis Strain: Unusual Cry Toxin Genes in a Highly Dynamic Plasmid Environment

Fayad, Nancy; Kambris, Zakaria; Chamy, Laure El; Mahillon, Jacques; Kallassy Awad, Mireille (American Society for Microbiology, 2021)

Bacillus thuringiensis has emerged as a major bioinsecticide on the global market. It offers a valuable alternative to chemical products classically utilized to control pest insects. Despite the efficiency of several strains ...
A novel nonsense mutation in NPHS1: is aortic stenosis associated with congenital nephropathy?

Gharibeh, Lara; El-Rassy, Inaam; Soubra, Ayman; Safa, Raya; Fahed, A. K.L.; Tanos, Rachel; Arabi, Mariam Toufic; Kambris, Zakaria; Bitar, Fadi Fouad; Nemer, Georges M. (Springer India, 2015)
A novel role for CSRP1 in a lebanese family with congenital cardiac defects

Kamar, Amina A.; Fahed, Akl C.; Shibbani, Kamel; El Hachem, Nehme; Bou-Slaiman, Salim; Arabi, Mariam Toufic; Kurban, Mazen S.; Seidman, Jonathan G.; Seidman, Christine E.; Haidar, Rachid K.; Baydoun, Elias Abdel Hasan; Nemer, Georges M.; Bitar, Fadi Fouad (Frontiers Media S.A., 2017)

Despite an obvious role for consanguinity in congenital heart disease (CHD), most studies fail to document a monogenic model of inheritance except for few cases. We hereby describe a first-degree cousins consanguineous ...
A Novel Somatic Variant in HEY2 Unveils an Alternative Splicing Isoform Linked to Ventricular Septal Defect

Fardoun, Manal Muin; Dehaini, Hassan; Kamar, Amina A.; Bitar, Fadi Fouad; Majdalani, Marianne Nimah; El-Rassi, Issam M.; Nemer, Georges M.; Arabi, Mariam Toufic (Springer New York LLC, 2019)

Congenital heart defects (CHDs) are the leading cause of death in infants under 1 year of age. Aberrations in the expression and function of cardiac transcription factors (TFs) are a major contributor to CHDs. Despite the ...
A risk progression breast epithelial 3D culture model reveals Cx43/hsa_circ_0077755/miR-182 as a biomarker axis for heightened risk of breast cancer initiation

Naser Al Deen, Nataly; Atallah Lanman, Nadia M.; Chittiboyina, Shirisha; Lelièvre, Sophie; Nasr, Rihab R.; Nassar, Farah J.; Zu Dohna, Heinrich; AbouHaidar, Mounir Georges; Talhouk, Rabih S. (Nature Research, 2021)

mRNA-circRNA-miRNAs axes have been characterized in breast cancer, but not as risk-assessment axes for tumor initiation in early-onset breast cancer that is increasing drastically worldwide. To address this gap, we performed ...
A river runs through it: Tree frog genomics supports the Dead Sea Rift as a rare phylogeographical break

Dufresnes, Christophe; Mazepa, Glib O.; Jablonski, Daniel; Sadek, Riyad A.; Litvinchuk, Spartak N. (Oxford University Press, 2019)

Phylogeographical breaks can be viewed as regional hotspots of diversity where the genetic integrity of incipient species is put to the test. We focus on an understudied species transition from the Middle East, namely the ...
A serine protease homolog negatively regulates TEP1 consumption in systemic infections of the malaria vector Anopheles gambiae

Yassine, Hassan; Kamareddine, Layla; Chamat, Soulaïma S.; Christophides, George K.; Osta, Mike A. (S. Karger AG, 2014)

Clip domain serine protease homologs are widely distributed in insect genomes and play important roles in regulating insect immune responses, yet their exact functions remain poorly understood. Here, we show that CLIPA2, ...
A signature of four circulating micrornas as potential biomarkers for diagnosing early-stage breast cancer

Itani, Maha M.; Nassar, Farah J.; Tfayli, Arafat Hussein; Talhouk, Rabih S.; Chamandi, Ghada K.; Itani, Abdulrahman S.; Makoukji, Joelle; Boustany, Rose Mary Naaman; Hou, Lifang; Khoueiry-Zgheib, Nathalie; Nasr, Rihab R. (MDPI, 2021)

Breast cancer (BC) is the most predominant type of cancer among women. The aim of this study is to find new biomarkers that can help in early detection of BC, especially for those who are too young to be screened using ...
A thiosemicarbazone derivative induces triple negative breast cancer cell apoptosis: possible role of miRNA-125a-5p and miRNA-181a-5p

El-Majzoub, Rania; Fayyad-Kazan, Mohammad; Nasr El Dine, Assaad; Makki, Rawan; Hamade, Eva; Gréé, Renè L.; Hachem, Ali; Talhouk, Rabih S.; Fayyad-kazan, Hussein; Badran, Bassam M. (Genetics Society of Korea, 2019)

Background: Breast cancer, the most commonly diagnosed malignancy in women, accounts for the highest cancer-related deaths worldwide. Triple negative breast cancer (TNBC), lacking the expression of estrogen, progesterone ...
A transgenic Drosophila melanogaster model to study human T-lymphotropic virus oncoprotein Tax-1-driven transformation in vivo

Shirinian, Margret; Kambris, Zakaria; Hamadeh, Lama N.; Grabbe, Caroline; Journo, Chloé; Mahieux, Renaud; Bazarbachi, Ali Abdul Hamid (American Society for Microbiology, 2015)

Human T-cell lymphotropic virus type 1 (HTLV-1)-induced adult T-cell leukemia/lymphoma is an aggressive malignancy. HTLV-2 is genetically related to HTLV-1 but does not cause any malignant disease. HTLV-1 Tax transactivator ...
Abundance patterns at the invasion front: The case of Siganus luridus in Linosa (Strait of Sicily, Central Mediterranean Sea)

Azzurro, Ernesto; Franzitta, G.; Milazzo, Marco; Bariche, Michel; Fanelli, E. (CSIRO, 2017)

The dusky spinefoot (Siganus luridus) has spread through much of the eastern Mediterranean since its introduction in 1920. In the present study, we monitored the abundance of this invader around the island of Linosa (Strait ...
Additive effect of MCP in combination with cefotaxime against staphylococcus aureus

Dahdouh, Elias A.; El-Khatib, Salah; Baydoun, Elias Abdel Hasan; Abdel-Massih, Roula (Bentham Science Publishers B.V., 2017)

Background: Pectin is a heterogeneous polysaccharide present in plants and citrus fruits. It exhibits different beneficial biological activities. Conflicting reports exist about the antimicrobial effect of pectin and its ...
Adverse effect of FTY720P on colonic Na+/K+ ATPase is mediated via ERK, p38MAPK, PKC, and PI3K

Rida, Reem; Hodeify, Rawad F.; Kreydiyyeh, Sawsan Ibrahim (John Wiley and Sons Ltd, 2023)

FTY720P, an analogue of sphingosine 1-phosphate, has emerged lately as a potential causative agent of inflammatory bowel disease, in which electrolytes movements driven by the sodium gradient established by the Na+/K+ ...
Aligning terrestrial habitat typology of Lebanon with EUNIS habitat classification

El Zein, Hicham; Stephan, Jean M.; Khater, Carla; Al-Zein, Mohammad Souheil; Bou Dagher Kharrat, Magda (Schweizerbart Science Publishers, 2022)

The absence of nationally accepted typology to classify and describe habitats has been an obstacle to the development of coordinated research in this field and to the implementation of conservation actions; therefore, a ...

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Browsing Department of Biology by Title

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