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Browsing Pharmacology and Toxicology by Issue Date

Now showing items 1-20 of 298

Improved accuracy of anticoagulant dose prediction using a pharmacogenetic and artificial neural network-based method

Isma’eel, Hussain A.; Sakr, George E.; Habib, Robert H.; Almedawar, Mohamad Musbah; Khoueiry-Zgheib, Nathalie; Elhajj, Imad H. (2014)

Background: The unpredictability of acenocoumarol dose needed to achieve target blood thinning level remains a challenge. We aimed to apply and compare a pharmacogenetic least-squares model (LSM) and artificial neural ...
MiRNA as potential biomarkers of breast cancer in the lebanese population and in young women: A pilot study

Nassar, Farah J.; Sabban, Maya El; Khoueiry-Zgheib, Nathalie; Tfayli, Arafat Hussein; Boulos, Fouad I.; Jabbour, Mark N.; El-Saghir, Nagi S.; Talhouk, Rabih S.; Bazarbachi, Ali Abdul Hamid; Calin, George Adrian; Nasr, Rihab R. (Public Library of Science, 2014)

Relative to western populations, the percentage of women diagnosed with breast cancer at a young age in Lebanon is high. While the younger age of the Lebanese population compared to the West certainly contributes to this ...
The Nutrigenetics and Pharmacogenetics of Vitamin D Pathways

Awada, Zainab; Ossaily, Safaa; Khoueiry-Zgheib, Nathalie (Bentham Science Publishers B.V., 2014)

In this manuscript, we review the literature on the nutrigenetics and pharmacogenetics of vitamin D pathways, with a focus on genes involved in the pharmacokinetic and pharmacodynamic pathways of vitamin D as they have ...
Genetic polymorphisms in candidate genes predict increased toxicity with methotrexate therapy in Lebanese children with acute lymphoblastic leukemia

Khoueiry-Zgheib, Nathalie; Akra-Ismail, Maya; Al-Aridi, Carol; Mahfouz, Rami A.R.; Abboud, Miguel Raul; El-Solh, Hassan; Muwakkit, Samar A. (Lippincott Williams and Wilkins, 2014)

BACKGROUND: The aim of this study is to analyze polymorphisms in genes involved in 6-mercaptopurine detoxification (TPMT); methotrexate (MTX) metabolism including ABCB1 (or MDR1), ABCC2, SLC19A1 (or RFC1), and SLCO1B1; and ...
Blockade of endothelin ETA, but not thromboxane, receptors offsets the cyclosporine-evoked hypertension and interrelated baroreflex and vascular dysfunctions

Nasser, Suzanne A.; ElMallah, Ahmed I.; Sabra, Ramzi F.; Khedr, Mohamed Mostafa; el-Din, Mahmoud Mohy; El-Mas, Mahmoud M. (2014)

The impairment of arterial baroreceptor and vasodilator functions are two major contributors to the hypertensive action of cyclosporine (CSA). In this study, in vivo and in vitro pharmacological studies were performed to ...
Interest and Involvement in Research During Medical School: a Global Comparison of Students at High- and Low-Income Universities

Salloum, Rony H.; Nazha, Bassel; Khoueiry-Zgheib, Nathalie (Springer, 2014)

Objectives: The objective of this study is to explore the attitudes, involvement, and knowledge of international medical students regarding research, as well as the barriers they face. Methods: This is a cross-sectional ...
The role of genetic polymorphisms in endothelial nitric oxide synthase and beta2-adrenergic receptors with risk of hypertension in a sample of Lebanese people

Soudani, Nadia Y.; Fakhoury, Rajaa M.; Kaissi, Samira S.; Khoueiry-Zgheib, Nathalie (Saudi Arabian Armed Forces Hospital, 2014)

Objectives: To determine the allelic frequencies of endothelial nitric oxide synthase (eNOS) and beta2- adrenergic receptor (ADRB2) genetic polymorphisms in a sample of Lebanese participants, and to test their association ...
The pharmacogenetics of drug metabolizing enzymes in the Lebanese population

Ossaily, Safaa; Khoueiry-Zgheib, Nathalie (Walter de Gruyter GmbH, 2014)

Drug metabolizing enzymes (DMEs) play a major role in the metabolism and final elimination of most drugs and xenobiotics from the body. Both phase I and phase II enzymes are highly polymorphic. Most studies on the ...
Use of technology in the readiness assurance process of team based learning: Paper, automated response system, or computer based testing

Antoun, Jumana M.; Nasr, Rihab R.; Khoueiry-Zgheib, Nathalie (Elsevier Ltd, 2015)

This qualitative study aimed at comparing and contrasting the feasibility, efficiency, and students' attitudes toward the use of paper, automated response system (ARS) and computer based testing (CBT) in the readiness ...
BRCA1 and BRCA2 mutations in ethnic lebanese Arab womenwith high hereditary risk breast cancer

El-Saghir, Nagi S.; Khoueiry-Zgheib, Nathalie; Assi, Hussein A.; Khoury, Katia E.; Bidet, Yannick; Jaber, Sara M.; Charara, Raghid N.; Farhat, Rania A.; Kreidieh, Firas Y.; Decousus, Stéphanie; Romero, Pierre; Nemer, Georges M.; Salem, Ziad M.; Shamseddine, Ali I.; Tfayli, Arafat Hussein; Abbas, Jaber S.; Jamali, Faek R.; Seoud, Muhieddine A.F.; Armstrong, Deborah Kay; Bignon, Yves Jean; Uhrhammer, Nancy A. (AlphaMed Press, 2015)

Purpose. Breast cancer is the most common malignancy among women in Lebanon and in Arab countries, with 50% of cases presenting before the age of 50 years. Methods. Between 2009 and 2012, 250 Lebanesewomenwith breastcanc ...
Using Team-Based Learning to Teach Grade 7 Biology: Student satisfaction and improved performance

Jarjoura, Christiane; Tayeh, Paula Abou; Khoueiry-Zgheib, Nathalie (Routledge, 2015)

Team-based learning (TBL) is an innovative form of collaborative learning. The purpose of this study was to evaluate TBL's effect on the performance and satisfaction of grade 7 students in biology in a private school in ...
Effects of CYP2B6 genetic polymorphisms in patients receiving cyclophosphamide combination chemotherapy for breast cancer

Haroun, Faysal; Al-Shaar, Laila; Habib, Robert H.; El-Saghir, Nagi S.; Tfayli, Arafat Hussein; Bazarbachi, Ali Abdul Hamid; Salem, Ziad M.; Shamseddine, Ali I.; Taher, Ali T.; Cascorbi, Ingolf; Khoueiry-Zgheib, Nathalie (Springer Verlag, 2015)

Purpose: The purpose of this study was to measure the frequency of three CYP2B6 [CYP2B6∗4 (rs2279343), CYP2B6∗5 (rs3211371) and CYP2B6∗9 (rs3745274)] alleles in patients with breast cancer receiving cyclophosphamide (CP) ...
Mechanical stretch-induced vascular hypertrophy occurs through modulation of leptin synthesis-mediated ROS formation and GATA-4 nuclear translocation

Ghantous, Crystal M.; Kobeissy, Firas H.; Soudani, Nadia Y.; Rahman, Farah Abdel; Al Hariri, Moustafa; Itani, Hana A.; Sabra, Ramzi F.; Zeidan, Asad (Frontiers Research Foundation, 2015)

Background: Obesity and hypertension are associated with increased leptin production contributing to cardiovascular remodeling. Mechanisms involving mechanical stretch-induced leptin production and the cross talk between ...
Differential Role of Leptin and Adiponectin in Cardiovascular System

Ghantous, Crystal M.; Azrak, Zeina; Hanache, S.; Abou-Kheir, Wassim G.; Zeidan, Asad (Hindawi Limited, 2015)

Leptin and adiponectin are differentially expressed adipokines in obesity and cardiovascular diseases. Leptin levels are directly associated with adipose tissue mass, while adiponectin levels are downregulated in obesity. ...
The pharmacoepigenetics of drug metabolism and transport in breast cancer: review of the literature and in silico analysis

Nasr, Rihab R.; Sleiman, Fatima; Awada, Zainab; Khoueiry-Zgheib, Nathalie (Future Medicine Ltd., 2016)

The focus of this manuscript is on DNA methylation and miRNA regulation of drug-metabolizing enzymes and drug transporters involved in the disposition of drugs commonly used in breast cancer. We start with a review of the ...
Inflammogenesis of secondary spinal cord injury

Anwar, M. Akhtar; Al-Shehabi, Tuqa Saleh; Eid, Ali H. (Frontiers Media S.A., 2016)

Spinal cord injury (SCI) and spinal infarction lead to neurological complications and eventually to paraplegia or quadriplegia. These extremely debilitating conditions are major contributors to morbidity. Our understanding ...
Cardiac STAT3 deficiency impairs contractility and metabolic homeostasis in hypertension

Altara, Raffaele; Harmancey, Romain N.; Didion, Sean P.; Booz, George Warren; Zouein, Fouad A. (Frontiers Research Foundation, 2016)

Signal transducer and activator of transcription 3 (STAT3) protects the heart from acute ischemic stress. However, the importance of STAT3 to the heart in chronic stress, such as hypertension, is not known. To study this, ...
Anti-atherosclerotic plants which modulate the phenotype of vascular smooth muscle cells

Saleh Al-Shehabi, Tuqa; Iratni, Rabah; Eid, Ali H. (Elsevier GmbH, 2016)

Background: Cardiovascular disease (CVD) remains the leading cause of global death, with atherosclerosis being a major contributor to this mortality. Several mechanisms are implicated in the pathogenesis of this disease. ...
Anti-hypertensive herbs and their mechanisms of action: Part I

Al Disi, Sara S.; Anwar, M. Akhtar; Eid, Ali H. (Frontiers Media S.A., 2016)

The use of herbal therapies for treatment and management of cardiovascular diseases (CVDs) is increasing. Plants contain a bounty of phytochemicals that have proven to be protective by reducing the risk of various ailments ...
The effect of increased lipoproteins levels on the disposition of vincristine in rat

Khalil, Hadeel A.; Belal, Tarek Saied; El-Yazbi, Ahmed F.; Hamdy, Dalia A. (BioMed Central Ltd., 2016)

Background: Vincristine (VCR), an antineoplastic agent, is a key component in the treatment of acute lymphoblastic leukemia, lymphomas, rhabdomyosarcoma, neuroblastoma, and Wilms' tumor diseases. Recently, high incidence ...

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Browsing Pharmacology and Toxicology by Issue Date

Browsing Pharmacology and Toxicology by Issue Date

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