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Browsing Pharmacology and Toxicology - Faculty Publications by Title

Now showing items 1-20 of 47

Alcohol spray vs. intradermal lidocaine before intravenous cannulation

Ayoub C.M.; Azar M.S.; Nasr V.G.; El-Khatib M.F.; Simaan J. (PHILADELPHIA530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA, 2008)

[No abstract available]
Alternating ibuprofen and acetaminophen in the treatment of febrile children: A pilot study [ISRCTN30487061]

Nabulsi M.M.; Tamim H.; Mahfoud Z.; Itani M.; Sabra R.; Chamseddine F.; Mikati M. (LONDONMIDDLESEX HOUSE, 34-42 CLEVELAND ST, LONDON W1T 4LB, ENGLAND, 2006)

Background: Alternating ibuprofen and acetaminophen for the treatment of febrile children is a prevalent practice among physicians and parents, despite the lack of evidence on effectiveness or safety. This randomized, ...
Approach to pediatric epilepsy surgery: State of the art, Part I: General principles and presurgical workup

Obeid M.; Wyllie E.; Rahi A.C.; Mikati M.A. (OXFORDTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND, 2009)

In 1990, the National Institute of Health adopted epilepsy surgery in children as an option when medications fail. In the past few years several concepts have become increasingly recognized as key to a successful approach ...
Approach to pediatric epilepsy surgery: State of the art, Part II: Approach to specific epilepsy syndromes and etiologies

Obeid M.; Wyllie E.; Rahi A.C.; Mikati M.A. (OXFORDTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND, 2009)

The second of this 2-part review depicts the specific approach to the common causes of pediatric refractory epilepsy amenable to surgery. These include tumors, malformations due to abnormal cortical development, vascular ...
Association between angiotensin-converting enzyme insertion-deletion genetic polymorphism and hypertension in a sample of Lebanese patients

Akra-Ismail M.; Makki R.F.; Chmaisse H.N.; Kazma A.; Zgheib N.K. (NEW ROCHELLE140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA, 2010)

Background-Aim: Several studies have looked at the potential link between angiotensin-converting enzyme (ACE) insertion-deletion (I-D) polymorphism and the risk of hypertension and have shown that the DD polymorphism may ...
Atypical Systemic Leishmaniasis to Be Considered in the Differential of Patients Presenting with Depressed Immunity

Nuwayri-Salti N.; Knio K.; Jammoul A.; Fakhoury R.; Sarhane K.A.; Nakkash-Chmaisse H. (SAN FRANCISCO1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA, 2012)

Background: Systemic leishmaniasis has been known to present with prolonged fever, hepatosplenomegaly and wasting. Beside this classical form, a sub-clinical form has been identified. It is described with either one or two ...
Blockade of endothelin ETA, but not thromboxane, receptors offsets the cyclosporine-evoked hypertension and interrelated baroreflex and vascular dysfunctions

Nasser S.A.; Elmallah A.I.; Sabra R.; Khedr M.M.; El-Din M.M.M.; El-Mas M.M. (AMSTERDAMPO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS, 2014)

The impairment of arterial baroreceptor and vasodilator functions are two major contributors to the hypertensive action of cyclosporine (CSA). In this study, in vivo and in vitro pharmacological studies were performed to ...
Clinical implementation of pharmacogenetics: A nonrepresentative explorative survey to participants of WorldPharma 2010

Ghaddar F.; Cascorbi I.; Zgheib N.K. (LONDONUNITEC HOUSE, 3RD FLOOR, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON, N3 1QB, ENGLAND, 2011)

Despite the fast-growing literature and the emerging support from regulatory drug agencies, the translation of pharmacogenetics (PGx) into the clinic is still rather limited; it seems that many existing challenges are yet ...
Clinical pharmacy and pharmacology: Indispensable expertise in modern and advanced pharmacotherapeutics

Simaan J.A. (, 2006)

[No abstract available]
Comparison of job and career satisfaction between women physicians and women academicians at the American University of Beirut

Zgheib N.; Zgheib P.W.; Usta J. (, 2006)

This study assesses the level of job and career satisfaction, work, social life and child care conflict of full time female academic physicians, and compares it with full time female non medical academicians at the American ...
Crowd-funded micro-grants for genomics and big data: An actionable idea connecting small (Artisan) science, infrastructure science, and citizen philanthropy

Ozdemir V.; Badr K.F.; Dove E.S.; Endrenyi L.; Geraci C.J.; Hotez P.J.; Milius D.; Neves-Pereira M.; Pang T.; Rotimi C.N.; Sabra R.; Sarkissian C.N.; Srivastava S.; Tims H.; Zgheib N.K.; Kickbusch I. (NEW ROCHELLE140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA, 2013)

Biomedical science in the 21st century is embedded in, and draws from, a digital commons and Big Data created by high-throughput Omics technologies such as genomics. Classic Edisonian metaphors of science and scientists ...
CYP2C19 genetic polymorphism, rabeprazole and esomeprazole have no effect on the antiplatelet action of clopidogrel

El-Halabi M.M.; Zgheib N.; Mansour N.M.; Malli A.; Ghaith O.A.; Mahfouz R.; Alam S.; Sharara A.I. (PHILADELPHIA530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA, 2013)

The aim of this study is to investigate the effect of CYP2C19 polymorphism and cotherapy with rabeprazole or esomeprazole on the antiplatelet effect of clopidogrel. Patients receiving clopidogrel 75 mg ± rabeprazole or ...
Cytochrome P4502E1 (CYP2E1) genetic polymorphisms in a lebanese population: Frequency distribution and association with morbid diseases

Zgheib N.K.; Mitri Z.; Geryess E.; Noutsi P. (NEW ROCHELLE140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA, 2010)

Background: The drug-metabolizing enzyme CYP2E1 is of great interest in environmental medicine because of its involvement in the bioactivation of multiple procarcinogens. Aim: This study is aimed at determining the frequency ...
Early and severe liver disease associated with homozygosity for an exon 7 mutation, G691R, in Wilson's disease [2]

Barada K.; Nemer G.; Elhajj I.I.; Touma J.; Cortas N.; Boustany R.-M.; Usta J. (OXFORD9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND, 2007)

[No abstract available]
Education may improve the underutilization of genetic services by Middle Eastern primary care practitioners

Antoun J.; Zgheib N.K.; Ashkar K. (NEW ROCHELLE140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA, 2010)

Aim: This study assesses Arab Middle Eastern primary care practitioners' (PCPs) use of and referral to clinical genetic testing and counseling, as well as the effect of education on their willingness to utilize or refer ...
Effect of chronic administration of sildenafil on sodium retention and on the hemodynamic complications associated with liver cirrhosis in the rat

Ghali-Ghoul R.; Tahseldar-Roumieh R.; Sabra R. (AMSTERDAMPO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS, 2007)

Previous studies demonstrated increased phosphodiesterase-5 (PDE5) activity and expression in the kidneys of rats with liver cirrhosis. Acute intravenous administration of PDE5 inhibitors enhanced sodium excretion in these ...
Effect of phosphodiesterase 5 inhibitor on alteration in vascular smooth muscle sensitivity and renal function in rats with liver cirrhosis

Tahseldar-Roumieh R.; Ghali-Ghoul R.; Lugnier C.; Sabra R. (BETHESDA9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA, 2006)

Previous studies suggested that increased activity of phosphodiesterase (PDE)5 in the kidneys of cirrhotic rats contributes to sodium retention. This study examined the role of PDE5 in the changes in vascular reactivity, ...
Equal antipyretic effectiveness of oral and rectal acetaminophen: A randomized controlled trial [ISRCTNI 1886401]

Nabulsi M.; Tamim H.; Sabra R.; Mahfoud Z.; Malaeb S.; Fakih H.; Mikati M. (, 2005)

Background: The antipyretic effectiveness of rectal versus oral acetaminophen is not well established. This study is designed to compare the antipyretic effectiveness of two rectal acetaminophen doses (15 mg-kg) and (35 ...
Genetic polymorphisms in candidate genes predict increased toxicity with methotrexate therapy in Lebanese children with acute lymphoblastic leukemia

Zgheib N.K.; Akra-Ismail M.; Aridi C.; Mahfouz R.; Abboud M.R.; Solh H.; Muwakkit S.A. (Lippincott Williams and Wilkins; PHILADELPHIA530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA, 2014)

BACKGROUND: The aim of this study is to analyze polymorphisms in genes involved in 6-mercaptopurine detoxification (TPMT); methotrexate (MTX) metabolism including ABCB1 (or MDR1), ABCC2, SLC19A1 (or RFC1), and SLCO1B1; and ...
Genetic polymorphisms of CYP2E1, GST, and NAT2 enzymes are not associated with risk of breast cancer in a sample of Lebanese women

Zgheib N.K.; Shamseddine A.A.; Geryess E.; Tfayli A.; Bazarbachi A.; Salem Z.; Shamseddine A.; Taher A.; El-Saghir N.S. (AMSTERDAMPO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS, 2013)

Changes in the activity of drug metabolizing enzymes (DMEs) are potentially associated with cancer risk. This relationship is attributed to their involvement in the bioactivation of multiple procarcinogens or the metabolism ...

Now showing items 1-20 of 47

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Browsing Pharmacology and Toxicology - Faculty Publications by Title

Browsing Pharmacology and Toxicology - Faculty Publications by Title

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