Browsing Pharmacology and Toxicology by Title

Now showing items 1-20 of 298

7-O-methylpunctatin, a novel homoisoflavonoid, inhibits phenotypic switch of human arteriolar smooth muscle cells

Fardoun, Manal Muin; Iratni, Rabah; Dehaini, Hassan; Eid, Assaad A.; Ghaddar, Tarek H.; El-Elimat, Tamam M.; Alali, Feras Qasem; Badran, Adnan; Eid, Ali H.; Baydoun, Elias Abdel Hasan (MDPI AG, 2019)

Remodeling of arterioles is a pivotal event in the manifestation of many inflammation-based cardio-vasculopathologies, such as hypertension. During these remodeling events, vascular smooth muscle cells (VSMCs) switch from ...
A cross-sectional survey on community pharmacists readiness to fight COVID-19 in a developing country: knowledge, attitude, and practice in Lebanon

Zeenny, Rony M.; Dimassi, Ahmad I.; Sacre, Hala; El-Khoury, Ghada M.; Hajj, Aline; Farah, Rita; Hajj, Hind; Lahoud, Nathalie A.; Akel, Marwan G.; Hallit, Souheil R.; Salameh, Pascale R. (BioMed Central Ltd, 2021)

Background: Lebanon, a developing Middle Eastern country, was hit by the COVID-19 pandemic that occurred amid a severe national economic crisis. Community pharmacists are responsible for dispensing appropriate medications ...
A GRIN3A polymorphism may be associated with glucocorticoid-induced symptomatic osteonecrosis in children with acute lymphoblastic leukemia

Khoueiry-Zgheib, Nathalie; El-Khoury, Habib; Maamari, Dimitri Jean Mickael; Basbous, Maya; Saab, Raya H.; Muwakkit, Samar A. (Future Medicine Ltd., 2021)

Aim: To evaluate the association between candidate genetic polymorphisms and glucocorticoid-induced osteonecrosis in Arab children treated for acute lymphoblastic leukemia. Methods: A total of 189 children treated for acute ...
A novel HPLC-DAD method for simultaneous determination of febuxostat and diclofenac in biological samples: Pharmacokinetic outcomes

El-Yazbi, Fawzy A.; Amin, Omayma Abdel Razak; El-Kimary, Eman I.; Khamis, Essam F.; Younis, Sameh E.; ElKhatib, Mohammed A.W.; El-Yazbi, Ahmed F. (Future Medicine Ltd., 2019)

Aim: To develop a simple HPLC-DAD method for simultaneous determination of febuxostat (FEB) and diclofenac (DIC) in biological samples to assess pharmacokinetic outcomes of their coadministration. Methodology & results: ...
A pilot assessment of the career and job satisfaction of the pharmaceutical workforce in Lebanon

Nassar, Elsa; Kassouf, Sibelle; Hajj, Aline; Sacre, Hala; Akel, Marwan G.; Zeenny, Rony M.; Haddad, Chadia; Salameh, Pascale R. (BioMed Central Ltd, 2022)

Background: Lebanon has been recognized as a center for high-quality healthcare services in the Middle East because of its prestigious facilities certified by international bodies, competent health workers, and credible ...
A population-based study of self-reported adverse drug events among Lebanese outpatients

Ramia, Elsy; Zeenny, Rony M.; Hallit, Souheil R.; Salameh, Pascale R. (Nature Research, 2021)

There is a limited number of studies assessing the epidemiology of Adverse Drug Events (ADEs) in the outpatient setting, especially those that do not result in healthcare use. The primary objective of this study was to ...
A potential link between oxidative stress and endothelial-to-mesenchymal transition in systemic sclerosis

Thuan, Duong Thi Bich; Zayed, Hatem; Eid, Ali H.; Abou-Saleh, Haissam; Nasrallah, G. K.; Mangoni, Arduino A.; Pintus, Gianfranco (Frontiers Media S.A., 2018)

Systemic sclerosis (SSc), an autoimmune disease that is associated with a number of genetic and environmental risk factors, is characterized by progressive fibrosis and microvasculature damage in the skin, lungs, heart, ...
A signature of four circulating micrornas as potential biomarkers for diagnosing early-stage breast cancer

Itani, Maha M.; Nassar, Farah J.; Tfayli, Arafat Hussein; Talhouk, Rabih S.; Chamandi, Ghada K.; Itani, Abdulrahman S.; Makoukji, Joelle; Boustany, Rose Mary Naaman; Hou, Lifang; Khoueiry-Zgheib, Nathalie; Nasr, Rihab R. (MDPI, 2021)

Breast cancer (BC) is the most predominant type of cancer among women. The aim of this study is to find new biomarkers that can help in early detection of BC, especially for those who are too young to be screened using ...
Academic pharmacist competencies in ordinary and emergency situations: content validation and pilot description in Lebanese academia

Safwan, Jihan H.; Akel, Marwan G.; Sacre, Hala; Haddad, Chadia; Sakr, Fouad R.; Hajj, Aline; Zeenny, Rony M.; Iskandar, Katia A.; Salameh, Pascale R. (BioMed Central Ltd, 2023)

Background: In the absence of a similar study in the Lebanese context, this study aimed to validate the content of the specialized competencies frameworks of academic pharmacists (educators, researchers, and clinical ...
Acute exposure to cigarette smoking followed by myocardial infarction aggravates renal damage in an in vivo mouse model

Kobeissy, Firas H.; Shaito, Abdullah A.; Kaplan, Abdullah; Baki, Lama; Hayek, Hassan; Dagher-Hamalian, Carole; Nehme, Ali; Ghali, Rana; Abidi, Emna; Husari, Ahmad W.; Zeidan, Asad; Zouein, Fouad A.; Zibara, Kazem (Hindawi Limited, 2017)

Cigarette smoking (S) is a risk factor for progressive chronic kidney disease, renal dysfunction, and renal failure. In this study, the effect of smoking on kidney function was investigated in a mouse model of myocardial ...
Adherence to treatment and harmful effects of medication shortages in the context of severe crises: scale validation and correlates

Bou Malhab, Sandrella; Haddad, Chadia; Sacre, Hala; Hajj, Aline; Zeenny, Rony M.; Akel, Marwan G.; Salameh, Pascale R. (BioMed Central Ltd, 2023)

Background: Medication shortage is a public health problem, affecting patients’ outcomes mainly through the difficulty in maintaining adherence, particularly in the context of a severe economic crisis. There is a need for ...
Adipose biology, cardiovascular, and cardiometabolic disease: Novel insights and new targets for intervention

El-Yazbi, Ahmed F.; Oudit, Gavin Y. (Portland Press Ltd, 2020)

Adipose biology research has grown rapidly offering new insights into the physiological and pathophysiological roles of different body fat depots. This Thematic Collection of Clinical Science brings a well-rounded timely ...
Adipose tissue immunomodulation: A novel therapeutic approach in cardiovascular and metabolic diseases

AlZaim, Ibrahim; Hammoud, Safaa; Al-Koussa, Houssam; Ghazi, Alaa; Eid, Ali H.; El-Yazbi, Ahmed F. (Frontiers Media S.A., 2020)

Adipose tissue is a critical regulator of systemic metabolism and bodily homeostasis as it secretes a myriad of adipokines, including inflammatory and anti-inflammatory cytokines. As the main storage pool of lipids, ...
Adipose tissue mitochondrial dysfunction and cardiometabolic diseases: On the search for novel molecular targets

AlZaim, Ibrahim; Eid, Ali H.; Abd-Elrahman, Khaled S.; El-Yazbi, Ahmed F. (Elsevier Inc., 2022)

Cardiometabolic diseases present an escalating global health and economic burden. Such a surge is driven by epidemic prevalence rates of metabolic disorders, such as obesity and type 2 diabetes, and their associated ...
Advances in cardiovascular biomarker discovery

Ghantous, Crystal M.; Kamareddine, Layla; Farhat, Rima; Zouein, Fouad A.; Mondello, Stefania; Kobeissy, Firas H.; Zeidan, Asad (MDPI AG, 2020)

Cardiovascular diseases are the leading causes of mortality worldwide. Among them, hypertension and its pathological complications pose a major risk for the development of other cardiovascular diseases, including heart ...
Amelioration of perivascular adipose inflammation reverses vascular dysfunction in a model of nonobese prediabetic metabolic challenge: potential role of antidiabetic drugs

ElKhatib, Mohammed A.W.; Mroueh, Ali; Rafeh, Rim W.; Sleiman, Fatima; Fouad, Hosny; Saad, Evan I.; Fouda, Mohamed A.; Elgaddar, Ola H.; Issa, Khodr; Eid, Ali H.; Eid, Assaad A.; Abd-Elrahman, Khaled S.; El-Yazbi, Ahmed F. (Mosby Inc., 2019)

The onset of vascular impairment precedes that of diagnostic hyperglycemia in diabetic patients suggesting a vascular insult early in the course of metabolic dysfunction without a well-defined mechanism. Mounting evidence ...
An update on the tissue renin angiotensin system and its role in physiology and pathology

Nehme, Ali; Zouein, Fouad A.; Zayeri, Zeinab Deris; Zibara, Kazem (MDPI, 2019)

In its classical view, the renin angiotensin system (RAS) was defined as an endocrine system involved in blood pressure regulation and body electrolyte balance. However, the emerging concept of tissue RAS, along with the ...
Anti-atherosclerotic plants which modulate the phenotype of vascular smooth muscle cells

Saleh Al-Shehabi, Tuqa; Iratni, Rabah; Eid, Ali H. (Elsevier GmbH, 2016)

Background: Cardiovascular disease (CVD) remains the leading cause of global death, with atherosclerosis being a major contributor to this mortality. Several mechanisms are implicated in the pathogenesis of this disease. ...
Anti-hypertensive herbs and their mechanisms of action: Part I

Al Disi, Sara S.; Anwar, M. Akhtar; Eid, Ali H. (Frontiers Media S.A., 2016)

The use of herbal therapies for treatment and management of cardiovascular diseases (CVDs) is increasing. Plants contain a bounty of phytochemicals that have proven to be protective by reducing the risk of various ailments ...
Anti-hypertensive herbs and their mechanisms of action: Part II

Anwar, M. Akhtar; Al Disi, Sara S.; Eid, Ali H. (Frontiers Media S.A., 2016)

Traditional medicine has a history extending back to thousands of years, and during the intervening time, man has identified the healing properties of a very broad range of plants. Globally, the use of herbal therapies to ...

Now showing items 1-20 of 298

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Browsing Pharmacology and Toxicology by Title

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